5-(tert-butyl)-3-((tert-butyl(cyclohexylmethyl)amino)methyl)-4'-chloro-3'-(trifluoromethyl)[1,1'-biphenyl]-2-ol

Base Information

Chemical Name:5-(tert-butyl)-3-((tert-butyl(cyclohexylmethyl)amino)methyl)-4'-chloro-3'-(trifluoromethyl)[1,1'-biphenyl]-2-ol
CAS No.:1609573-50-3
Molecular Formula:C₂₉H₃₉ClF₃NO
Molecular Weight:510.083
Hs Code.:

Synonyms:5-(tert-butyl)-3-((tert-butyl(cyclohexylmethyl)amino)methyl)-4'-chloro-3'-(trifluoromethyl)[1,1'-biphenyl]-2-ol

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Chemical Property of 5-(tert-butyl)-3-((tert-butyl(cyclohexylmethyl)amino)methyl)-4'-chloro-3'-(trifluoromethyl)[1,1'-biphenyl]-2-ol

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Technology Process of 5-(tert-butyl)-3-((tert-butyl(cyclohexylmethyl)amino)methyl)-4'-chloro-3'-(trifluoromethyl)[1,1'-biphenyl]-2-ol

There total 3 articles about 5-(tert-butyl)-3-((tert-butyl(cyclohexylmethyl)amino)methyl)-4'-chloro-3'-(trifluoromethyl)[1,1'-biphenyl]-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3,6-di-tert-butyl-8-(4-chloro-3-(trifluoromethyl)phenyl)-3,4-dihydro-2H-benzo[e][1,3]oxazine

: 931-51-1
cyclohexylmagnesiumchloride

: 1609573-50-3
5-(tert-butyl)-3-((tert-butyl(cyclohexylmethyl)amino)methyl)-4'-chloro-3'-(trifluoromethyl)[1,1'-biphenyl]-2-ol

Guidance literature:: In tetrahydrofuran; diethyl ether; at 3 - 25 ℃; for 2h;

Reference yield:

: 176976-42-4
(4-chloro-3-(trifluoromethyl)phenyl)boronic acid

: 1609573-50-3
5-(tert-butyl)-3-((tert-butyl(cyclohexylmethyl)amino)methyl)-4'-chloro-3'-(trifluoromethyl)[1,1'-biphenyl]-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; diethylene glycol dimethyl ether / 16 h / 66 - 78 °C / Inert atmosphere

2: tetrahydrofuran; diethyl ether / 2 h / 3 - 25 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; diethyl ether; diethylene glycol dimethyl ether; water;

Reference yield:

: 1609573-33-2
8-bromo-3,6-di-tert-butyl-3,4-dihydro-2H-benzo[e][1,3]oxazine

: 1609573-50-3
5-(tert-butyl)-3-((tert-butyl(cyclohexylmethyl)amino)methyl)-4'-chloro-3'-(trifluoromethyl)[1,1'-biphenyl]-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; diethylene glycol dimethyl ether / 16 h / 66 - 78 °C / Inert atmosphere

2: tetrahydrofuran; diethyl ether / 2 h / 3 - 25 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; diethyl ether; diethylene glycol dimethyl ether; water;