2-chloro-5-[(2-methyl-4-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrrol-1-yl)-methyl]pyridine

Base Information

Chemical Name:2-chloro-5-[(2-methyl-4-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrrol-1-yl)-methyl]pyridine
CAS No.:1225380-38-0
Molecular Formula:C₂₀H₁₄ClF₃N₄O₂
Molecular Weight:434.805
Hs Code.:

Synonyms:2-chloro-5-[(2-methyl-4-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrrol-1-yl)-methyl]pyridine

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Chemical Property of 2-chloro-5-[(2-methyl-4-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrrol-1-yl)-methyl]pyridine

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Technology Process of 2-chloro-5-[(2-methyl-4-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrrol-1-yl)-methyl]pyridine

There total 7 articles about 2-chloro-5-[(2-methyl-4-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrrol-1-yl)-methyl]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: N'-hydroxy-4-(trifluoromethoxy) benzene-1-carboximidamide

: 1225380-36-8
1-[(6-chloropyridin-3-yl)methyl]-5-methyl-1H-pyrrole-3-carboxylic acid

: 1225380-38-0
2-chloro-5-[(2-methyl-4-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrrol-1-yl)-methyl]pyridine

Guidance literature:: 1-[(6-chloropyridin-3-yl)methyl]-5-methyl-1H-pyrrole-3-carboxylic acid; With oxalyl dichloride; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;

N'-hydroxy-4-(trifluoromethoxy) benzene-1-carboximidamide; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h;

Reference yield:

: N'-hydroxy-4-(trifluoromethoxy) benzene-1-carboximidamide

: C₁₂H₁₀Cl₂N₂O

: 1225380-38-0
2-chloro-5-[(2-methyl-4-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrrol-1-yl)-methyl]pyridine

Guidance literature:: N'-hydroxy-4-(trifluoromethoxy) benzene-1-carboximidamide; C₁₂H₁₀Cl₂N₂O; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;

In dimethyl sulfoxide; at 140 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 1225380-37-9
methyl 1-[(6-chloropyridin-3-yl)methyl]-5-methyl-1H-pyrrole-3-carboxylate

: 1225380-38-0
2-chloro-5-[(2-methyl-4-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrrol-1-yl)-methyl]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; methanol / 15 h / 20 °C / Reflux

2.1: oxalyl dichloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

3.2: 0.5 h / 140 °C / Microwave irradiation

With methanol; oxalyl dichloride; triethylamine; sodium hydroxide; In dichloromethane;