(7aS,3S)-3-piperidino-1,2,5,6,7,7a-hexahydro-2-(phenylmethyl)pyrrolo<1,2-c><1,3,2>-diazaphosphole 3-oxide

Base Information

Chemical Name:(7aS,3S)-3-piperidino-1,2,5,6,7,7a-hexahydro-2-(phenylmethyl)pyrrolo<1,2-c><1,3,2>-diazaphosphole 3-oxide
CAS No.:189107-17-3
Molecular Formula:C₁₇H₂₆N₃OP
Molecular Weight:319.387
Hs Code.:

Synonyms:(7aS,3S)-3-piperidino-1,2,5,6,7,7a-hexahydro-2-(phenylmethyl)pyrrolo<1,2-c><1,3,2>-diazaphosphole 3-oxide

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Chemical Property of (7aS,3S)-3-piperidino-1,2,5,6,7,7a-hexahydro-2-(phenylmethyl)pyrrolo<1,2-c><1,3,2>-diazaphosphole 3-oxide

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Technology Process of (7aS,3S)-3-piperidino-1,2,5,6,7,7a-hexahydro-2-(phenylmethyl)pyrrolo<1,2-c><1,3,2>-diazaphosphole 3-oxide

There total 5 articles about (7aS,3S)-3-piperidino-1,2,5,6,7,7a-hexahydro-2-(phenylmethyl)pyrrolo<1,2-c><1,3,2>-diazaphosphole 3-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1498-56-2
piperidin-1-yl-phosphonic acid dichloride

: 75773-76-1
(S)‐N‐benzyl‐1‐(pyrrolidin‐2‐yl) methanamine

: 189107-17-3
(7aS,3S)-3-piperidino-1,2,5,6,7,7a-hexahydro-2-(phenylmethyl)pyrrolo<1,2-c><1,3,2>-diazaphosphole 3-oxide

: (7aS,3R)-3-piperidino-1,2,5,6,7,7a-hexahydro-2-(phenylmethyl)pyrrolo<1,2-c><1,3,2>-diazaphosphole 3-oxide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1021/jo9820723

Reference yield:

: 121611-64-1
(S)-benzyl 2-(benzylcarbamoyl)pyrrolidine-1-carboxylate

: 189107-17-3
(7aS,3S)-3-piperidino-1,2,5,6,7,7a-hexahydro-2-(phenylmethyl)pyrrolo<1,2-c><1,3,2>-diazaphosphole 3-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / methanol

2: LiAlH₄ / tetrahydrofuran

3: 45 percent / Et₃N / tetrahydrofuran / 3 h / 20 °C

With lithium aluminium tetrahydride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jo9820723

Reference yield:

: 100-46-9
benzylamine

: 189107-17-3
(7aS,3S)-3-piperidino-1,2,5,6,7,7a-hexahydro-2-(phenylmethyl)pyrrolo<1,2-c><1,3,2>-diazaphosphole 3-oxide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) ClCOOC₂H₅, Et₃N

2: H₂ / Pd/C / methanol

3: LiAlH₄ / tetrahydrofuran

4: 45 percent / Et₃N / tetrahydrofuran / 3 h / 20 °C

With lithium aluminium tetrahydride; hydrogen; chloroformic acid ethyl ester; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jo9820723