benzyl 2-(2-fluorophenyl)ethanethioate

Base Information

• Chemical Name: benzyl 2-(2-fluorophenyl)ethanethioate
• CAS No.: 1631041-44-5
• Molecular Formula: C₁₅H₁₃FOS
• Molecular Weight: 260.332
• Mol file: 1631041-44-5.mol

Synonyms:benzyl 2-(2-fluorophenyl)ethanethioate

Chemical Property of benzyl 2-(2-fluorophenyl)ethanethioate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of benzyl 2-(2-fluorophenyl)ethanethioate

There total 1 articles about benzyl 2-(2-fluorophenyl)ethanethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

phenylmethanethiol (100-53-8) + (2-fluorophenyl)acetic acid (451-82-1) → benzyl 2-(2-fluorophenyl)ethanethioate (1631041-44-5)

Guidance literature:

(2-fluorophenyl)acetic acid; With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 0.0333333h; Inert atmosphere;

phenylmethanethiol; In dichloromethane; at 0 - 25 ℃; for 4.25h; Inert atmosphere;

DOI:10.1002/ejoc.201400142

Reference yield: 83.0%

benzyl 2-(2-fluorophenyl)ethanethioate (1631041-44-5) + N-(4-bromobenzylidene)benzylamine (27046-29-3) → benzyl 2S*,3R*-3-(benzylamino)-2-(4-bromophenyl)-3-(2-fluorophenyl)thiopropanoate

Guidance literature:

benzyl 2-(2-fluorophenyl)ethanethioate; N-(4-bromobenzylidene)benzylamine; With titanium tetrachloride; In dichloromethane; at -78 ℃;

With triethylamine; In dichloromethane; at 0 ℃; for 6h; diastereoselective reaction;

DOI:10.1002/ejoc.201400142

Reference yield:

benzyl 2-(2-fluorophenyl)ethanethioate (1631041-44-5) → C22H17BrFNO

Guidance literature:

Multi-step reaction with 2 steps

1.1: titanium tetrachloride / dichloromethane / -78 °C

1.2: 6 h / 0 °C

2.1: mercury(II) trifluoroacetate / acetonitrile / 0.17 h / 25 °C / Inert atmosphere

With mercury(II) trifluoroacetate; titanium tetrachloride; In dichloromethane; acetonitrile; 1.1: |Mannich Aminomethylation;

DOI:10.1002/ejoc.201400142

upstream raw materials:

phenylmethanethiol

(2-fluorophenyl)acetic acid