(rac)-7-(4-cyanophenyl)-2-methoxy-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

Base Information

Chemical Name:(rac)-7-(4-cyanophenyl)-2-methoxy-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile
CAS No.:1234620-12-2
Molecular Formula:C₂₂H₁₅F₃N₆O
Molecular Weight:436.396
Hs Code.:

Synonyms:(rac)-7-(4-cyanophenyl)-2-methoxy-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

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Chemical Property of (rac)-7-(4-cyanophenyl)-2-methoxy-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

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Technology Process of (rac)-7-(4-cyanophenyl)-2-methoxy-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

There total 4 articles about (rac)-7-(4-cyanophenyl)-2-methoxy-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1234620-76-8
(rac)-7-(4-cyanophenyl)-2-methoxy-5-methyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

: 1423-26-3
(meta-(trifluoromethyl)phenyl)boronic acid

: 1234620-12-2
(rac)-7-(4-cyanophenyl)-2-methoxy-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

Guidance literature:: (rac)-7-(4-cyanophenyl)-2-methoxy-5-methyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile; (meta-(trifluoromethyl)phenyl)boronic acid; With pyridine; copper diacetate; triethylamine; In dichloromethane; at 20 ℃; for 48h; Inert atmosphere; Molecular sieve;

With 2,6-dimethylpyridine; copper diacetate; In dichloromethane; at 20 ℃; for 168h;

Reference yield:

: 1234620-56-4
4-(2-cyano-3-oxobut-1-en-1-yl)benzonitrile

: 1234620-12-2
(rac)-7-(4-cyanophenyl)-2-methoxy-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine; rac-Pro-OH / N,N-dimethyl-formamide / 96 h / Inert atmosphere; Molecular sieve

2.1: toluene-4-sulfonic acid; pyridine / toluene / 1 h / Reflux

3.1: triethylamine; pyridine; copper diacetate / dichloromethane / 48 h / 20 °C / Inert atmosphere; Molecular sieve

3.2: 168 h / 20 °C

With pyridine; copper diacetate; toluene-4-sulfonic acid; triethylamine; rac-Pro-OH; In dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1234620-77-9
4-[1-(5-amino-3-methoxy-1H-1,2,4-triazol-1-yl)-2-cyano-3-oxobutyl]benzonitrile

: 1234620-12-2
(rac)-7-(4-cyanophenyl)-2-methoxy-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid; pyridine / toluene / 1 h / Reflux

2.1: triethylamine; pyridine; copper diacetate / dichloromethane / 48 h / 20 °C / Inert atmosphere; Molecular sieve

2.2: 168 h / 20 °C

With pyridine; copper diacetate; toluene-4-sulfonic acid; triethylamine; In dichloromethane; toluene;