Technology Process of C25H24N2O2SSi
There total 5 articles about C25H24N2O2SSi which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N-ethynyl-4-methyl-N-(2-((trimethylsilyl)ethynyl)phenyl)benzenesulfonamide;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran;
at -78 - -40 ℃;
for 0.666667h;
Inert atmosphere;
With
zinc dibromide;
In
tetrahydrofuran;
for 0.333333h;
Inert atmosphere;
2-iodopyridine;
With
tris-(dibenzylideneacetone)dipalladium(0); triphenylphosphine;
In
tetrahydrofuran;
at 20 ℃;
for 12h;
Inert atmosphere;
DOI:10.1039/c1cc11298h
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere
2.1: pyridine / tetrahydrofuran / 20 °C / Inert atmosphere
3.1: potassium hexamethylsilazane / toluene / 0.5 h / 0 °C / Inert atmosphere
3.2: 0 - 20 °C / Inert atmosphere
4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.67 h / -78 - -40 °C / Inert atmosphere
4.2: 0.33 h / Inert atmosphere
4.3: 12 h / 20 °C / Inert atmosphere
With
pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium hexamethylsilazane; triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; N,N-dimethyl-formamide; toluene;
1.1: Sonogashira coupling / 4.3: Negishi coupling reaction;
DOI:10.1039/c1cc11298h
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: pyridine / tetrahydrofuran / 20 °C / Inert atmosphere
2.1: potassium hexamethylsilazane / toluene / 0.5 h / 0 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.67 h / -78 - -40 °C / Inert atmosphere
3.2: 0.33 h / Inert atmosphere
3.3: 12 h / 20 °C / Inert atmosphere
With
pyridine; potassium hexamethylsilazane; lithium hexamethyldisilazane;
In
tetrahydrofuran; toluene;
3.3: Negishi coupling reaction;
DOI:10.1039/c1cc11298h
