(1S,4S)-4-(trifluoromethyl)-2,3,4,9-tetrahydro-1-phenyl-1H-pyrido[3,4-b]indole

Base Information

Chemical Name:(1S,4S)-4-(trifluoromethyl)-2,3,4,9-tetrahydro-1-phenyl-1H-pyrido[3,4-b]indole
CAS No.:1275518-78-9
Molecular Formula:C₁₈H₁₅F₃N₂
Molecular Weight:316.326
Hs Code.:

Synonyms:(1S,4S)-4-(trifluoromethyl)-2,3,4,9-tetrahydro-1-phenyl-1H-pyrido[3,4-b]indole

Suppliers and Price of (1S,4S)-4-(trifluoromethyl)-2,3,4,9-tetrahydro-1-phenyl-1H-pyrido[3,4-b]indole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1S,4S)-4-(trifluoromethyl)-2,3,4,9-tetrahydro-1-phenyl-1H-pyrido[3,4-b]indole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S,4S)-4-(trifluoromethyl)-2,3,4,9-tetrahydro-1-phenyl-1H-pyrido[3,4-b]indole

There total 8 articles about (1S,4S)-4-(trifluoromethyl)-2,3,4,9-tetrahydro-1-phenyl-1H-pyrido[3,4-b]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 120-72-9
indole

: (1R,4S)-4-(trifluoromethyl)-2,3,4,9-tetrahydro-1-phenyl-1H-pyrido[3,4-b]indole

: 1275518-78-9
(1S,4S)-4-(trifluoromethyl)-2,3,4,9-tetrahydro-1-phenyl-1H-pyrido[3,4-b]indole

Guidance literature:: Multi-step reaction with 5 steps

1.1: copper(II) bis(trifluoromethanesulfonate); 2,2-bis[(4S)-4-isopropyloxazolin-2-yl]propane / diethyl ether / 0.33 h / 20 °C / Inert atmosphere

1.2: 10 h / -35 °C / Inert atmosphere

2.1: potassium hydroxide / ethanol / 16 h / 20 °C / Inert atmosphere

3.1: diphenyl phosphoryl azide; triethylamine / toluene / 3 h / 50 °C / Inert atmosphere

3.2: 80 °C / Inert atmosphere

4.1: magnesium sulfate / dichloromethane / 0.5 h / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 72 h / 20 °C / Inert atmosphere

With diphenyl phosphoryl azide; copper(II) bis(trifluoromethanesulfonate); magnesium sulfate; triethylamine; trifluoroacetic acid; potassium hydroxide; 2,2-bis[(4S)-4-isopropyloxazolin-2-yl]propane; In diethyl ether; ethanol; dichloromethane; toluene; 1.2: Friedel-Crafts alkylation;
DOI:10.1021/jo1024333

Reference yield:

: 1275517-81-1
diethyl (R)-2-(2,2,2-trifluoro-1-(1H-indol-3-yl)ethyl)malonate

: (1R,4S)-4-(trifluoromethyl)-2,3,4,9-tetrahydro-1-phenyl-1H-pyrido[3,4-b]indole

: 1275518-78-9
(1S,4S)-4-(trifluoromethyl)-2,3,4,9-tetrahydro-1-phenyl-1H-pyrido[3,4-b]indole

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / ethanol / 16 h / 20 °C / Inert atmosphere

2.1: diphenyl phosphoryl azide; triethylamine / toluene / 3 h / 50 °C / Inert atmosphere

2.2: 80 °C / Inert atmosphere

3.1: magnesium sulfate / dichloromethane / 0.5 h / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 72 h / 20 °C / Inert atmosphere

With diphenyl phosphoryl azide; magnesium sulfate; triethylamine; trifluoroacetic acid; potassium hydroxide; In ethanol; dichloromethane; toluene;
DOI:10.1021/jo1024333

Reference yield:

: 1275518-59-6
(3R)-2-(ethoxycarbonyl)-4,4,4-trifluoro-3-(1H-indol-3-yl)butanoic acid

: (1R,4S)-4-(trifluoromethyl)-2,3,4,9-tetrahydro-1-phenyl-1H-pyrido[3,4-b]indole

: 1275518-78-9
(1S,4S)-4-(trifluoromethyl)-2,3,4,9-tetrahydro-1-phenyl-1H-pyrido[3,4-b]indole

Guidance literature:: Multi-step reaction with 3 steps

1.1: diphenyl phosphoryl azide; triethylamine / toluene / 3 h / 50 °C / Inert atmosphere

1.2: 80 °C / Inert atmosphere

2.1: magnesium sulfate / dichloromethane / 0.5 h / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 72 h / 20 °C / Inert atmosphere

With diphenyl phosphoryl azide; magnesium sulfate; triethylamine; trifluoroacetic acid; In dichloromethane; toluene;
DOI:10.1021/jo1024333