(3S,3'S)-1,1'-dibenzyl-3,3'-bis-(2-hydroxyethyl)-[3,3'-biindoline]-2,2'-dione

Base Information

Chemical Name:(3S,3'S)-1,1'-dibenzyl-3,3'-bis-(2-hydroxyethyl)-[3,3'-biindoline]-2,2'-dione
CAS No.:247061-40-1
Molecular Formula:C₃₄H₃₂N₂O₄
Molecular Weight:532.639
Hs Code.:

Synonyms:(3S,3'S)-1,1'-dibenzyl-3,3'-bis-(2-hydroxyethyl)-[3,3'-biindoline]-2,2'-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S,3'S)-1,1'-dibenzyl-3,3'-bis-(2-hydroxyethyl)-[3,3'-biindoline]-2,2'-dione

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (3S,3'S)-1,1'-dibenzyl-3,3'-bis-(2-hydroxyethyl)-[3,3'-biindoline]-2,2'-dione

There total 44 articles about (3S,3'S)-1,1'-dibenzyl-3,3'-bis-(2-hydroxyethyl)-[3,3'-biindoline]-2,2'-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: diethyl 2,2'-((3S,3'S)-1,1'-dibenzyl-2,2'-dioxo-[3,3'-biindoline]-3,3'-diyl)diacetate

: 247061-40-1
(3S,3'S)-1,1'-dibenzyl-3,3'-bis-(2-hydroxyethyl)-[3,3'-biindoline]-2,2'-dione

Guidance literature:: With lithium borohydride; In methanol; diethyl ether; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1021/acs.orglett.8b02327

Reference yield:

: 371252-55-0
2,2'-((3S,3'S)-1,1'-dibenzyl-2,2'-dioxo-[3,3'-biindoline]-3,3'-diyl)diacetaldehyde

: 247061-40-1
(3S,3'S)-1,1'-dibenzyl-3,3'-bis-(2-hydroxyethyl)-[3,3'-biindoline]-2,2'-dione

Guidance literature:: With sodium tetrahydroborate; In methanol;
DOI:10.1021/ja991714g

Reference yield:

: 120-72-9
indole

: 247061-40-1
(3S,3'S)-1,1'-dibenzyl-3,3'-bis-(2-hydroxyethyl)-[3,3'-biindoline]-2,2'-dione

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium carbonate / water / 2.5 h / 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h / 0 °C / Inert atmosphere

2.2: 2 h / 0 °C / Inert atmosphere

3.1: triethylsilane; trifluoroacetic acid / dichloromethane / 0.58 h / 20 °C / Inert atmosphere

4.1: triethylamine / tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere

4.2: 1 h / 0 °C / Inert atmosphere

5.1: dmap / dichloromethane / 12 h / 20 °C / Inert atmosphere

6.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R,R)-ANDEN-phenyl Trost ligand / diethyl ether / 7 h / -25 °C / Inert atmosphere

7.1: dimethyl sulfoxide; acetic acid; hydrogenchloride / water / 2 h / 25 °C / Inert atmosphere

8.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h / 0 - 25 °C / Inert atmosphere

8.2: 0 - 25 °C / Inert atmosphere

9.1: 4-methylmorpholine N-oxide; osmium(VIII) oxide / dichloromethane; water / 25 °C / Inert atmosphere

10.1: sodium tetrahydroborate / methanol / 0.25 h / 0 °C / Inert atmosphere

With hydrogenchloride; triethylsilane; dmap; sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; osmium(VIII) oxide; (R,R)-ANDEN-phenyl Trost ligand; sodium hydride; potassium carbonate; acetic acid; dimethyl sulfoxide; 4-methylmorpholine N-oxide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/chem.201502878