(R)-8-((3-(5-amino-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)amino)pyrido[2,3-d]pyridazine-3-carbonitrile

Base Information

Chemical Name:(R)-8-((3-(5-amino-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)amino)pyrido[2,3-d]pyridazine-3-carbonitrile
CAS No.:1600508-22-2
Molecular Formula:C₂₁H₂₀FN₇O₂S
Molecular Weight:453.5
Hs Code.:

Synonyms:(R)-8-((3-(5-amino-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)amino)pyrido[2,3-d]pyridazine-3-carbonitrile

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Chemical Property of (R)-8-((3-(5-amino-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)amino)pyrido[2,3-d]pyridazine-3-carbonitrile

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Technology Process of (R)-8-((3-(5-amino-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)amino)pyrido[2,3-d]pyridazine-3-carbonitrile

There total 10 articles about (R)-8-((3-(5-amino-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)amino)pyrido[2,3-d]pyridazine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.74%

: 1600511-18-9
N-(3-((3R)-5-amino-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-3-bromopyrido[2,3-d]pyridazin-8-amine

: 1600508-22-2
(R)-8-((3-(5-amino-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)amino)pyrido[2,3-d]pyridazine-3-carbonitrile

Guidance literature:: In N,N-dimethyl-formamide;

Reference yield:

: 909186-02-3
3-bromopyrido[2,3-d]pyridazin-8(7H)-one

: 1600508-22-2
(R)-8-((3-(5-amino-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)amino)pyrido[2,3-d]pyridazine-3-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate

2: sulfuric acid

3: N,N-dimethyl-formamide

With sulfuric acid; trichlorophosphate; In N,N-dimethyl-formamide;

Reference yield:

: 1600511-35-0
tert-butyl ((2R)-2-(5-bromo-2-fluorophenyl)-1-((1-cyanoethyl)thio)propan-2-yl)carbamate

: 1600508-22-2
(R)-8-((3-(5-amino-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)amino)pyrido[2,3-d]pyridazine-3-carbonitrile

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / methanol; dihydrogen peroxide; N,N-dimethyl-formamide; ethyl acetate

2: hydrogenchloride / 1,4-dioxane

3: sodium hydrogencarbonate / 1,4-dioxane

4: sodium azide / water; ethanol

5: water; tetrahydrofuran

6: sulfuric acid

7: N,N-dimethyl-formamide

With hydrogenchloride; sodium azide; sulfuric acid; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; dihydrogen peroxide; ethyl acetate; N,N-dimethyl-formamide;