dimethyl 6,6'-dibenzyloxy-5,5'-dimethoxybiphenyl-2,2'-dicarboxylate

Base Information

• Chemical Name: dimethyl 6,6'-dibenzyloxy-5,5'-dimethoxybiphenyl-2,2'-dicarboxylate
• CAS No.: 135586-22-0
• Molecular Formula: C₃₂H₃₀O₈
• Molecular Weight: 542.585
• Mol file: 135586-22-0.mol

Synonyms:dimethyl 6,6'-dibenzyloxy-5,5'-dimethoxybiphenyl-2,2'-dicarboxylate

Chemical Property of dimethyl 6,6'-dibenzyloxy-5,5'-dimethoxybiphenyl-2,2'-dicarboxylate

Chemical Property:

• Solubility.: Dichloromethane, Ethyl Acetate

Purity/Quality:

6,6’-Dibenzyloxy-5,5’-dimethoxy-2,2’-diphenicAcidDimethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl 6,6'-dibenzyloxy-5,5'-dimethoxybiphenyl-2,2'-dicarboxylate

There total 10 articles about dimethyl 6,6'-dibenzyloxy-5,5'-dimethoxybiphenyl-2,2'-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methyl 3-benzyloxy-2-bromo-4-methoxybenzoate (135586-19-5) → dimethyl 6,6'-dibenzyloxy-5,5'-dimethoxybiphenyl-2,2'-dicarboxylate (135586-22-0)

Guidance literature:

With copper; In N,N-dimethyl-formamide; at 150 - 160 ℃; for 4h; Inert atmosphere;

DOI:10.1055/s-0029-1217393

Reference yield: 39.0%

2-Bromo-4-methoxy-3-methoxycarbonyloxy-6-methyl-benzoic acid methyl ester (135586-18-4) + methyl 3-benzyloxy-2-bromo-4-methoxybenzoate (135586-19-5) → dimethyl 6,6'-dibenzyloxy-5,5'-dimethoxybiphenyl-2,2'-dicarboxylate (135586-22-0) + 6'-Benzyloxy-5,5'-dimethoxy-6-methoxycarbonyloxy-3-methyl-biphenyl-2,2'-dicarboxylic acid dimethyl ester (135586-20-8)

Guidance literature:

With copper; at 220 - 240 ℃;

DOI:10.1080/00397919108019768

Reference yield:

2-bromoisovanillin (2973-58-2) → dimethyl 6,6'-dibenzyloxy-5,5'-dimethoxybiphenyl-2,2'-dicarboxylate (135586-22-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 87 percent / K₂CO₃ / dimethylformamide / 14 h

2: 84 percent / Jones' reagent / acetone / 24 h

3: 86 percent / 5percent aq. H₂SO₄

4: 1.6 g / copper bronze / 220 - 240 °C

With jones' reagent; sulfuric acid; copper; potassium carbonate; In N,N-dimethyl-formamide; acetone;

DOI:10.1080/00397919108019768

upstream raw materials:

2-Bromo-4-methoxy-3-methoxycarbonyloxy-6-methyl-benzoic acid methyl ester

methyl 3-benzyloxy-2-bromo-4-methoxybenzoate

2-bromoisovanillin

2-methyl-4-methoxy-5-hydroxybenzaldehyde