Pyridine-2-carboximidohydrazide

Base Information

• Chemical Name: Pyridine-2-carboximidohydrazide
• CAS No.: 1005-02-3
• Deprecated CAS: 53612-72-9
• Molecular Formula: C6H8 N4
• Molecular Weight: 136.156
• Hs Code.: 2933399090
• European Community (EC) Number: 213-731-7
• Mol file: 1005-02-3.mol

Synonyms:Pyridine-2-carboximidohydrazide;Pyridine-2-hydrazidine;EINECS 213-731-7;2-Pyridine amidrazone;C6H8N4;C6-H8-N4;1005-02-3;SCHEMBL12560610;AKOS003615439

Chemical Property of Pyridine-2-carboximidohydrazide

Chemical Property:

• Vapor Pressure: 0.00019mmHg at 25°C
• Melting Point: 95-96 °C
• Refractive Index: 1.646
• Boiling Point: 328.4°C at 760 mmHg
• PKA: 7.38±0.50(Predicted)
• Flash Point: 152.4°C
• PSA: 74.79000
• Density: 1.31g/cm³
• LogP: 1.06120
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 136.074896272
• Heavy Atom Count: 10
• Complexity: 132

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)C(=NN)N
• Isomeric SMILES: C1=CC=NC(=C1)/C(=N\N)/N

Technology Process of Pyridine-2-carboximidohydrazide

There total 9 articles about Pyridine-2-carboximidohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-Cyanopyridine (100-70-9,1232006-36-8) → pyridine-2-carboxamidrazone (1005-02-3)

Guidance literature:

With hydrazine hydrate; In ethanol; at 0 - 40 ℃; for 16h;

DOI:10.1002/jhet.2374

Reference yield: 92.0%

2-Cyanopyridine (100-70-9,1232006-36-8) → picolinamidrazone (1005-02-3)

Guidance literature:

With hydrazine hydrate; In ethanol; at 20 ℃; for 18h;

DOI:10.1039/c9tc00768g

Reference yield: 73.0%

2-Cyanopyridine (100-70-9,1232006-36-8) → 2-pyridinecarbohydrazonamide (1005-02-3)

Guidance literature:

With ethanol; hydrazine; at 20 ℃; for 48h;

upstream raw materials:

pyridine-2-carbothioamide

2-Cyanopyridine

pyridine-2-carboxamidine hydrochloride

Downstream raw materials:

5-(2-pyridyl)-1H-tetrazole

Refernces

• 1、 Chen, L.,Li, D.,Lin, M.,Ling, Q.,Liu, Ch.,Xing, G.. "Synthesis and Properties of Main-Chain Phosphorescent Polymer with Iridium Complex". . p. 2504 - 2511. Retrieved 2019.
• 2、 Pathaw, Larica,Khamrang, Themmila,Kathiravan, Arunkumar,Velusamy, Marappan. "Synthesis, crystal structure, bovine serum albumin binding studies of 1,2,4-triazine based copper(I) complexes". . . Retrieved 2020.
• 3、 Ahn, So Youn,Ha, Yunkyoung. "The blue phosphorescent iridium complexes containing new triazole ligands for OLEDs". . p. 59 - 66. Retrieved 2009.
• 4、 Xu, Huixia,Sun, Peng,Wang, Kexiang,Miao, Yanqin,Yang, Tingting,Wang, Hua,Xu, Bingshe,Wong, Wai-Yeung. "1,2,4-Triazole derivatives as host materials for blue and green phosphorescent organic light-emitting devices". . p. 4408 - 4413. Retrieved 2016.
• 5、 Adhikari, Sanjay,Sutradhar, Dipankar,Shepherd, Samantha L.,Phillips, Roger M.,Chandra, Asit K.,Rao, K. Mohan. "Synthesis, structural, DFT calculations and biological studies of rhodium and iridium complexes containing azine Schiff-base ligands". . p. 404 - 414. Retrieved 2016.
• 6、 Park, Hye Rim,Ha, Yunkyoung,Yi, Ye Young. "The blue phosphorescent iridium complexes containing the pyridyltriazole derivatives as a main ligand". . p. 156 - 162,7. Retrieved 2012.
• 7、 Diring, Stephane,Retailleau, Pascal,Ziessel, Raymond. "A rational protocol for the synthesis of arylated bipyridine ligands via a cycloaddition pathway". . p. 10181 - 10193. Retrieved 2007.
• 8、 Zvirzdinaite, Maryte,Garbe, Simon,Arefyeva, Natalia,Krause, Maren,Von Der Stück, René,Klein, Axel. "Palladium(II)complexes of ambidentate and potentially cyclometalating 5-aryl-3-(2′-pyridyl)-1,2,4-triazine ligands". . p. 2011 - 2022. Retrieved 2017.
• 9、 Shintou, Taichi,Ikeuchi, Fumiaki,Kuwabara, Hirokazu,Umihara, Ken,Itoh, Isamu. "Synthesis of 2-pyridylpyridines via aza-Diels-Alder reactions between 3-pyridyl-1,2,4-triazines and some vinyl alkanoates". . p. 836 - 837. Retrieved 2005.
• 10、 Dong, Guangbin,Xu, Yan,Zhou, Xukai. "Olefination via Cu-Mediated Dehydroacylation of Unstrained Ketones". supporting information. p. 20042 - 20048. Retrieved 2021/12/03.