2-Ethylpyrrolidine

Base Information

• Chemical Name: 2-Ethylpyrrolidine
• CAS No.: 1003-28-7
• Molecular Formula: C6H13 N
• Molecular Weight: 99.1759
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID20407335
• Nikkaji Number: J1.680.641B
• Mol file: 1003-28-7.mol

Synonyms:2-ethylpyrrolidine;1003-28-7;Pyrrolidine, 2-ethyl-;(R)-2-ethylpyrrolidine;MFCD02663413;2-Ethyl-pyrrolidine;Pyrrolidine, 2-ethyl;Pyrrolidine,2-ethyl-;DTXSID20407335;AKOS000155299;AKOS016343918;AB12042;SB44685;BB 0249481;FT-0683185;FT-0772287;EN300-51394;N12693;A800099;triammoniumdiaquaoctachloro-mu-nitridodiruthenate(3-);F8880-6440;Z281773802

Chemical Property of 2-Ethylpyrrolidine

Chemical Property:

• Vapor Pressure: 14.1mmHg at 25°C
• Melting Point: 119-123℃
• Refractive Index: 1.4442 (589.3 nm 15℃)
• Boiling Point: 122.1°Cat760mmHg
• PKA: 10.93±0.10(Predicted)
• Flash Point: 15.5°C
• PSA: 12.03000
• Density: 0.81g/cm³
• LogP: 1.47720
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 99.104799419
• Heavy Atom Count: 7
• Complexity: 52.1

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Ethylpyrrolidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1CCCN1
• Uses: 2-Ethylpyrrolidine Hydrochloride is used as a reagent in the synthesis of C-4” position substituted macrolide derivatives as antibacterial agents against erythromcyn-resistant bacteria.

Technology Process of 2-Ethylpyrrolidine

There total 22 articles about 2-Ethylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-aminohex-trans-4-ene (55108-01-5) → 2-ethyl-pyrrolidine (1003-28-7) + 2-Methylpiperidin (109-05-7,3000-79-1)

Guidance literature:

With bis(benzonitrile)palladium(II) dichloride; trifluorormethanesulfonic acid; hydrogen; diethylamine; Yield given. Multistep reaction. Yields of byproduct given;

DOI:10.1016/S0022-328X(00)85965-3

Reference yield:

2-ethyl-1H-pyrrole (1551-06-0) → 2-ethyl-pyrrolidine (1003-28-7)

Guidance literature:

With acetic acid; platinum; Hydrogenation;

Reference yield:

C20H25NO → 2-ethyl-pyrrolidine (1003-28-7)

Guidance literature:

With lead(IV) tetraacetate; In toluene; at 20 ℃; for 1h; Cooling with ice;

DOI:10.1016/j.mencom.2015.11.014

upstream raw materials:

2-ethyl-1-pyrroline

2-ethyl-1H-pyrrole

hexane-1,6-diamine dihydrochloride

1-aminohex-trans-4-ene

Downstream raw materials:

2-ethyl-1-(toluene-4-sulfonyl)-pyrrolidine

1-Methyl-2-ethyl-pyrrolidin

N-(6-(2-ethylpyrrolidin-1-yl)pyridin-2-yl)-6-phenylimidazo[1,2-b]pyridazin-8-amine hydrochloride

2-ethylpyrrolidine-1-carbonitrile

Refernces

• 1、 Nikishin, Gennady I.,Troyansky, Emmanuil I.,Lazareva, Margarita I.. "REGIOSPECIFIC OXIDATIVE CYCLIZATION OF N-METHANESULFONYLALKYLAMINES: A NEW METHOD OF PYRROLIDINE RING CONSTRUCTION". . p. 1877 - 1878. Retrieved 1985.
• 2、 Mueller,Wachs. "-". . p. 420. Retrieved 1929.
• 3、 Rosien, Michael,T?ben, Iris,Schmidtmann, Marc,Beckhaus, Rüdiger,Doye, Sven. "Titanium-Catalyzed Hydroaminoalkylation of Ethylene". supporting information. p. 2138 - 2142. Retrieved 2020/02/05.
• 4、 Moshkin, Vladimir S.,Sosnovskikh, Vyacheslav Ya.. "A novel synthesis of 2-alkyl(aryl)pyrrolidines from proline via 2,3-diphenylhexahydropyrrolo[2,1-b]oxazoles". . p. 440 - 442. Retrieved 2015/12/30.