Technology Process of (2S,3S)-3-Benzyloxycarbonylamino-2-(1-hydroxy-1-methyl-ethyl)-pentanedioic acid 5-methyl ester
There total 7 articles about (2S,3S)-3-Benzyloxycarbonylamino-2-(1-hydroxy-1-methyl-ethyl)-pentanedioic acid 5-methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium chlorite; sodium dihydrogen phosphate;
In
water; tert-butyl alcohol;
at 20 ℃;
for 0.5h;
DOI:10.1021/ol005596+
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 5.95 g / tetrahydrofuran
2: 4.3 g / hydrochloride (from early step) / CH2Cl2 / 2 h / Heating
3: 3.22 percent / sodium cyanoborohydride; 2N HCl; bromocresol / CH2Cl2; methanol; tetrahydrofuran / -90 - -20 °C
4: 3.63 g / sodium hydrogen carbonate / CH2Cl2; H2O / 1 h / 20 °C
5: meta-chloroperoxybenzoic acid / diethyl ether / 0.25 h / 20 °C
6: 960 mg / hydrochloric acid / tetrahydrofuran; H2O / 0.25 h / 20 °C
7: 880 mg / sodium chlorite; sodium dihydrogen phosphate / 2-methyl-propan-2-ol; various solvent(s); H2O / 0.5 h / 20 °C
With
hydrogenchloride; sodium chlorite; sodium dihydrogen phosphate; 2-bromo-6-methylphenol; sodium cyanoborohydride; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; tert-butyl alcohol;
1: Condensation / 2: Cycloaddition / 3: Reduction / 4: Substitution / 5: Oxidation / 6: Hydrolysis / 7: Oxidation;
DOI:10.1021/ol005596+
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 4.3 g / hydrochloride (from early step) / CH2Cl2 / 2 h / Heating
2: 3.22 percent / sodium cyanoborohydride; 2N HCl; bromocresol / CH2Cl2; methanol; tetrahydrofuran / -90 - -20 °C
3: 3.63 g / sodium hydrogen carbonate / CH2Cl2; H2O / 1 h / 20 °C
4: meta-chloroperoxybenzoic acid / diethyl ether / 0.25 h / 20 °C
5: 960 mg / hydrochloric acid / tetrahydrofuran; H2O / 0.25 h / 20 °C
6: 880 mg / sodium chlorite; sodium dihydrogen phosphate / 2-methyl-propan-2-ol; various solvent(s); H2O / 0.5 h / 20 °C
With
hydrogenchloride; sodium chlorite; sodium dihydrogen phosphate; 2-bromo-6-methylphenol; sodium cyanoborohydride; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; tert-butyl alcohol;
1: Cycloaddition / 2: Reduction / 3: Substitution / 4: Oxidation / 5: Hydrolysis / 6: Oxidation;
DOI:10.1021/ol005596+
