Acetic acid (R)-2,2-dimethyl-5-phenyl-2,5-dihydro-furan-3-yl ester

Base Information

• Chemical Name: Acetic acid (R)-2,2-dimethyl-5-phenyl-2,5-dihydro-furan-3-yl ester
• CAS No.: 131354-55-7
• Molecular Formula: C₁₄H₁₆O₃
• Molecular Weight: 232.279
• Mol file: 131354-55-7.mol

Synonyms:Acetic acid (R)-2,2-dimethyl-5-phenyl-2,5-dihydro-furan-3-yl ester

Chemical Property of Acetic acid (R)-2,2-dimethyl-5-phenyl-2,5-dihydro-furan-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of Acetic acid (R)-2,2-dimethyl-5-phenyl-2,5-dihydro-furan-3-yl ester

There total 3 articles about Acetic acid (R)-2,2-dimethyl-5-phenyl-2,5-dihydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

Acetic acid (R)-4-hydroxy-4-methyl-1-phenyl-pent-2-ynyl ester (131354-51-3) → Acetic acid (R)-2,2-dimethyl-5-phenyl-2,5-dihydro-furan-3-yl ester (131354-55-7)

Guidance literature:

With silver tetrafluoroborate; In benzene; at 40 ℃;

DOI:10.1021/jo00003a003

Reference yield:

(R)-4-Methyl-1-phenyl-pent-2-yne-1,4-diol (131354-47-7) → Acetic acid (R)-2,2-dimethyl-5-phenyl-2,5-dihydro-furan-3-yl ester (131354-55-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / pyridine / CH₂Cl₂ / Ambient temperature

2: 67 percent / AgBF₄ / benzene / 40 °C

With pyridine; silver tetrafluoroborate; In dichloromethane; benzene;

DOI:10.1021/jo00003a003

Reference yield:

5-acetoxy-2-methyl-5-phenyl-3-pentyn-2-ol (88865-31-0) → Acetic acid (R)-2,2-dimethyl-5-phenyl-2,5-dihydro-furan-3-yl ester (131354-55-7) + Acetic acid (S)-2,2-dimethyl-5-phenyl-2,5-dihydro-furan-3-yl ester

Guidance literature:

With silver tetrafluoroborate; In benzene; Yield given; Yields of byproduct given. Title compound not separated from byproducts; Heating;

DOI:10.1246/bcsj.72.279

upstream raw materials:

Acetic acid (R)-4-hydroxy-4-methyl-1-phenyl-pent-2-ynyl ester

5-acetoxy-2-methyl-5-phenyl-3-pentyn-2-ol

(R)-4-Methyl-1-phenyl-pent-2-yne-1,4-diol