(3aS,5S,6aR,7aS,8R,11R,11aS,11bS,11cS)-5,11-Dimethoxy-11c-(4-methoxy-benzyloxymethyl)-3,8,11a-trimethyl-1,3a,4,5,6a,7,7a,8,9,10,11,11a,11b,11c-tetradecahydro-6-oxa-benzo[de]anthracene

Base Information

Chemical Name:(3aS,5S,6aR,7aS,8R,11R,11aS,11bS,11cS)-5,11-Dimethoxy-11c-(4-methoxy-benzyloxymethyl)-3,8,11a-trimethyl-1,3a,4,5,6a,7,7a,8,9,10,11,11a,11b,11c-tetradecahydro-6-oxa-benzo[de]anthracene
CAS No.:125458-65-3
Molecular Formula:C₃₀H₄₄O₅
Molecular Weight:484.676
Hs Code.:

(3aS,5S,6aR,7aS,8R,11R,11aS,11bS,11cS)-5,11-Dimethoxy-11c-(4-methoxy-benzyloxymethyl)-3,8,11a-trimethyl-1,3a,4,5,6a,7,7a,8,9,10,11,11a,11b,11c-tetradecahydro-6-oxa-benzo[de]anthracene

Synonyms:(3aS,5S,6aR,7aS,8R,11R,11aS,11bS,11cS)-5,11-Dimethoxy-11c-(4-methoxy-benzyloxymethyl)-3,8,11a-trimethyl-1,3a,4,5,6a,7,7a,8,9,10,11,11a,11b,11c-tetradecahydro-6-oxa-benzo[de]anthracene

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Chemical Property of (3aS,5S,6aR,7aS,8R,11R,11aS,11bS,11cS)-5,11-Dimethoxy-11c-(4-methoxy-benzyloxymethyl)-3,8,11a-trimethyl-1,3a,4,5,6a,7,7a,8,9,10,11,11a,11b,11c-tetradecahydro-6-oxa-benzo[de]anthracene

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Technology Process of (3aS,5S,6aR,7aS,8R,11R,11aS,11bS,11cS)-5,11-Dimethoxy-11c-(4-methoxy-benzyloxymethyl)-3,8,11a-trimethyl-1,3a,4,5,6a,7,7a,8,9,10,11,11a,11b,11c-tetradecahydro-6-oxa-benzo[de]anthracene

There total 5 articles about (3aS,5S,6aR,7aS,8R,11R,11aS,11bS,11cS)-5,11-Dimethoxy-11c-(4-methoxy-benzyloxymethyl)-3,8,11a-trimethyl-1,3a,4,5,6a,7,7a,8,9,10,11,11a,11b,11c-tetradecahydro-6-oxa-benzo[de]anthracene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 125458-64-2
((3aS,5S,6aR,7aS,8R,11R,11aS,11bS,11cS)-5,11-Dimethoxy-3,8,11a-trimethyl-1,4,5,6a,7,7a,8,9,10,11,11a,11b-dodecahydro-3aH-6-oxa-benzo[de]anthracen-11c-yl)-methanol

: 824-94-2
p-methoxybenzyl chloride

: 125458-65-3
(3aS,5S,6aR,7aS,8R,11R,11aS,11bS,11cS)-5,11-Dimethoxy-11c-(4-methoxy-benzyloxymethyl)-3,8,11a-trimethyl-1,3a,4,5,6a,7,7a,8,9,10,11,11a,11b,11c-tetradecahydro-6-oxa-benzo[de]anthracene

Guidance literature:: With sodium hydride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at 70 ℃; for 14h;
DOI:10.1016/S0040-4039(00)99255-4

Reference yield:

: 123929-85-1
(+)-<4aR-(4aβ,5β,8α,8aα)>-4a,5,6,7,8,8a-hexahydro-4a,8-dimethyl-3-formyl-5-methoxy-2(1H)-naphthalenone

: 125458-65-3
(3aS,5S,6aR,7aS,8R,11R,11aS,11bS,11cS)-5,11-Dimethoxy-11c-(4-methoxy-benzyloxymethyl)-3,8,11a-trimethyl-1,3a,4,5,6a,7,7a,8,9,10,11,11a,11b,11c-tetradecahydro-6-oxa-benzo[de]anthracene

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / H₂O / 3 h

2: sodium borohydride / tetrahydrofuran; H₂O

3: 1) i-Bu₂AlH 2) cc.HCl / 1) THF, -40 deg C

4: 88 percent / sodium hydride / tetrahydrofuran; hexamethylphosphoric acid triamide / 14 h / 70 °C

With hydrogenchloride; sodium tetrahydroborate; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; water;
DOI:10.1016/S0040-4039(00)99255-4

Reference yield:

: 149400-06-6
(+)-(1β,9β)-20-hydroxy-1-methoxypicras-12-en-16-one

: 125458-65-3
(3aS,5S,6aR,7aS,8R,11R,11aS,11bS,11cS)-5,11-Dimethoxy-11c-(4-methoxy-benzyloxymethyl)-3,8,11a-trimethyl-1,3a,4,5,6a,7,7a,8,9,10,11,11a,11b,11c-tetradecahydro-6-oxa-benzo[de]anthracene

Guidance literature:: Multi-step reaction with 2 steps

1: 1) i-Bu₂AlH 2) cc.HCl / 1) THF, -40 deg C

2: 88 percent / sodium hydride / tetrahydrofuran; hexamethylphosphoric acid triamide / 14 h / 70 °C

With hydrogenchloride; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1016/S0040-4039(00)99255-4