C₁₂H₁₀BrF₂N

Base Information

Chemical Name:C₁₂H₁₀BrF₂N
CAS No.:1629023-50-2
Molecular Formula:C₁₂H₁₀BrF₂N
Molecular Weight:286.119
Hs Code.:

C<sub>12</sub>H<sub>10</sub>BrF<sub>2</sub>N

Synonyms:C₁₂H₁₀BrF₂N

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Chemical Property of C₁₂H₁₀BrF₂N

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Technology Process of C₁₂H₁₀BrF₂N

There total 6 articles about C₁₂H₁₀BrF₂N which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1629023-32-0
C₁₂H₁₀BrNO

: 1629023-50-2
C₁₂H₁₀BrF₂N

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at -20 ℃; for 2h;
DOI:10.1016/j.bmcl.2014.05.082

Reference yield:

: 1435-51-4
1,3-dibromo-5-fluorobenzene

: 1629023-50-2
C₁₂H₁₀BrF₂N

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / 1-methyl-pyrrolidin-2-one / 24 h / 120 °C

2.1: lithium chloride / dimethyl sulfoxide; water / 3 h / 165 °C

3.1: tetrabutylammomium bromide; sodium hydroxide / toluene; water / 16 h / 20 °C

4.1: copper(l) cyanide; TurboGrignard / tetrahydrofuran / 1 h / 0 - 20 °C

5.1: ozone / dichloromethane; methanol / 1 h / -78 °C

5.2: 16 h / -78 - 20 °C

6.1: diethylamino-sulfur trifluoride / dichloromethane / 2 h / -20 °C

With TurboGrignard; diethylamino-sulfur trifluoride; tetrabutylammomium bromide; copper(l) cyanide; sodium hydride; ozone; lithium chloride; sodium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; dimethyl sulfoxide; toluene; 2.1: |Krapcho Dealkoxycarbonylation;
DOI:10.1016/j.bmcl.2014.05.082

Reference yield:

: cyano-(3,5-dibromophenyl)acetic acid ethyl ester

: 1629023-50-2
C₁₂H₁₀BrF₂N

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium chloride / dimethyl sulfoxide; water / 3 h / 165 °C

2.1: tetrabutylammomium bromide; sodium hydroxide / toluene; water / 16 h / 20 °C

3.1: copper(l) cyanide; TurboGrignard / tetrahydrofuran / 1 h / 0 - 20 °C

4.1: ozone / dichloromethane; methanol / 1 h / -78 °C

4.2: 16 h / -78 - 20 °C

5.1: diethylamino-sulfur trifluoride / dichloromethane / 2 h / -20 °C

With TurboGrignard; diethylamino-sulfur trifluoride; tetrabutylammomium bromide; copper(l) cyanide; ozone; lithium chloride; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; toluene; 1.1: |Krapcho Dealkoxycarbonylation;
DOI:10.1016/j.bmcl.2014.05.082