Technology Process of 14-(3-acetoxy-4-methoxyphenyl)-2,11-diacetoxy-3,12-dimethoxy-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one
There total 12 articles about 14-(3-acetoxy-4-methoxyphenyl)-2,11-diacetoxy-3,12-dimethoxy-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
dichloromethane;
for 18h;
Heating;
DOI:10.1021/jo061810h
- Guidance literature:
-
Multi-step reaction with 10 steps
1: potassium carbonate / acetone / 6 h / Heating
2: acetic acid; ethylenediamine / 20 °C
3: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / 20 °C
4: sodium carbonate / dichloromethane; water / 2 h / 20 °C
5: trichlorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C
6: sodium hydrogencarbonate / acetonitrile / 18 h / Heating
7: hydrogen / palladium on activated charcoal / ethyl acetate / 20 °C / 3878.61 Torr
8: sodium hydride / tetrahydrofuran / 0 - 20 °C
9: dmap; triethylamine / dichloromethane / 4 h / 20 °C
10: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 18 h / Heating
With
dmap; lithium aluminium tetrahydride; hydrogen; sodium hydride; sodium hydrogencarbonate; sodium carbonate; potassium carbonate; acetic acid; ethylenediamine; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; trichlorophosphate;
palladium on activated charcoal;
In
tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; acetonitrile;
2: Knoevenagel reaction / 5: Bischler-Napieralski reaction;
DOI:10.1021/jo061810h
- Guidance literature:
-
Multi-step reaction with 8 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / 20 °C
2: sodium carbonate / dichloromethane; water / 2 h / 20 °C
3: trichlorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C
4: sodium hydrogencarbonate / acetonitrile / 18 h / Heating
5: hydrogen / palladium on activated charcoal / ethyl acetate / 20 °C / 3878.61 Torr
6: sodium hydride / tetrahydrofuran / 0 - 20 °C
7: dmap; triethylamine / dichloromethane / 4 h / 20 °C
8: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 18 h / Heating
With
dmap; lithium aluminium tetrahydride; hydrogen; sodium hydride; sodium hydrogencarbonate; sodium carbonate; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; trichlorophosphate;
palladium on activated charcoal;
In
tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
3: Bischler-Napieralski reaction;
DOI:10.1021/jo061810h
![14-(3-acetoxy-4-methoxyphenyl)-2,11-diacetoxy-3,12-dimethoxy-8,9-dihydro-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one](/Databaselist/images/loading.webp)
