[(1R,2R)-4-Benzenesulfonyl-2-methyl-1-((1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-ylmethyl)-butoxy]-tert-butyl-dimethyl-silane

Base Information

Chemical Name:[(1R,2R)-4-Benzenesulfonyl-2-methyl-1-((1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-ylmethyl)-butoxy]-tert-butyl-dimethyl-silane
CAS No.:378198-03-9
Molecular Formula:C₃₂H₅₄O₃SSi
Molecular Weight:546.93
Hs Code.:

[(1R,2R)-4-Benzenesulfonyl-2-methyl-1-((1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-ylmethyl)-butoxy]-tert-butyl-dimethyl-silane

Synonyms:[(1R,2R)-4-Benzenesulfonyl-2-methyl-1-((1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-ylmethyl)-butoxy]-tert-butyl-dimethyl-silane

Suppliers and Price of [(1R,2R)-4-Benzenesulfonyl-2-methyl-1-((1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-ylmethyl)-butoxy]-tert-butyl-dimethyl-silane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [(1R,2R)-4-Benzenesulfonyl-2-methyl-1-((1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-ylmethyl)-butoxy]-tert-butyl-dimethyl-silane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [(1R,2R)-4-Benzenesulfonyl-2-methyl-1-((1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-ylmethyl)-butoxy]-tert-butyl-dimethyl-silane

There total 16 articles about [(1R,2R)-4-Benzenesulfonyl-2-methyl-1-((1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-ylmethyl)-butoxy]-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 378198-02-8
[(E)-(1R,2R)-4-Benzenesulfonyl-2-methyl-1-((1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-ylmethyl)-but-3-enyloxy]-tert-butyl-dimethyl-silane

: 378198-03-9
[(1R,2R)-4-Benzenesulfonyl-2-methyl-1-((1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-ylmethyl)-butoxy]-tert-butyl-dimethyl-silane

Guidance literature:: With sodium tetrahydroborate; nickel dichloride; In methanol; at 0 ℃; for 3h;
DOI:10.1021/jo010154c

Reference yield:

: 38419-75-9
(1R,2R,4aS,8aS)-1-(2-hydroxyethyl)-2,5,5,8a-tetramethyl-decahydronaphthalen-2-ol

: 378198-03-9
[(1R,2R)-4-Benzenesulfonyl-2-methyl-1-((1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-ylmethyl)-butoxy]-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 11 steps

1.1: 99 percent / imidazole / dimethylformamide / 1 h / 20 °C

2.1: SOCl₂; 4-DMAP / pyridine / -50 - 0 °C

2.2: 62 percent / SeO₂; salicylic acid; tBuOOH / CH₂Cl₂ / 48 h / 20 °C

3.1: 17 percent / H₂ / Pd/C / ethanol / 12 h / 20 °C / 760.05 Torr

4.1: 98 percent / TBAF / tetrahydrofuran / 1 h / Heating

5.1: 96 percent / Et₃N; SO₃*Py / dimethylsulfoxide / 1 h / 20 °C

6.1: 87 percent / Bu₂BOTf; Et₃N / CH₂Cl₂ / -78 - 0 °C

7.1: 98 percent / AlMe₃ / toluene; CH₂Cl₂ / 24 h / 0 - 20 °C

8.1: 98 percent / 2,6-lutidine / CH₂Cl₂ / -78 - -10 °C

9.1: 99 percent / DIBALH / tetrahydrofuran / 0.5 h / -78 °C

10.1: 70 percent / NaH / tetrahydrofuran / 2 h / 20 °C

11.1: 92 percent / NiCl₂*xH₂O; NaBH₄ / methanol / 3 h / 0 °C

With 1H-imidazole; 2,6-dimethylpyridine; dmap; sodium tetrahydroborate; thionyl chloride; pyridine-SO₃ complex; di-n-butylboryl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; hydrogen; trimethylaluminum; sodium hydride; diisobutylaluminium hydride; triethylamine; nickel dichloride; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo010154c

Reference yield:

: 564-20-5,1216-84-8,30450-17-0,58976-28-6,64090-92-2,67844-42-2,79768-41-5,79768-42-6,86688-27-9,86688-28-0,95406-08-9,98719-44-9,98719-46-1,131831-65-7,140851-80-5
(3aR)-(+)-sclareolide

: 378198-03-9
[(1R,2R)-4-Benzenesulfonyl-2-methyl-1-((1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-ylmethyl)-butoxy]-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 12 steps

1.1: 100 percent / LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

2.1: 99 percent / imidazole / dimethylformamide / 1 h / 20 °C

3.1: SOCl₂; 4-DMAP / pyridine / -50 - 0 °C

3.2: 62 percent / SeO₂; salicylic acid; tBuOOH / CH₂Cl₂ / 48 h / 20 °C

4.1: 17 percent / H₂ / Pd/C / ethanol / 12 h / 20 °C / 760.05 Torr

5.1: 98 percent / TBAF / tetrahydrofuran / 1 h / Heating

6.1: 96 percent / Et₃N; SO₃*Py / dimethylsulfoxide / 1 h / 20 °C

7.1: 87 percent / Bu₂BOTf; Et₃N / CH₂Cl₂ / -78 - 0 °C

8.1: 98 percent / AlMe₃ / toluene; CH₂Cl₂ / 24 h / 0 - 20 °C

9.1: 98 percent / 2,6-lutidine / CH₂Cl₂ / -78 - -10 °C

10.1: 99 percent / DIBALH / tetrahydrofuran / 0.5 h / -78 °C

11.1: 70 percent / NaH / tetrahydrofuran / 2 h / 20 °C

12.1: 92 percent / NiCl₂*xH₂O; NaBH₄ / methanol / 3 h / 0 °C

With 1H-imidazole; 2,6-dimethylpyridine; dmap; sodium tetrahydroborate; lithium aluminium tetrahydride; thionyl chloride; pyridine-SO₃ complex; di-n-butylboryl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; hydrogen; trimethylaluminum; sodium hydride; diisobutylaluminium hydride; triethylamine; nickel dichloride; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo010154c