13CD₃-(7aS,8aR)-4-benzyl-8-methyl-7,7a,8,8a-tetrahydroazireno[2,3-c]imidazo[4,5,1-ij]quinolin-5(4H)-one

Base Information

• Chemical Name: 13CD₃-(7aS,8aR)-4-benzyl-8-methyl-7,7a,8,8a-tetrahydroazireno[2,3-c]imidazo[4,5,1-ij]quinolin-5(4H)-one
• CAS No.: 845612-99-9
• Molecular Formula: C₁₈H₁₇N₃O
• Molecular Weight: 295.318

Synonyms:13CD₃-(7aS,8aR)-4-benzyl-8-methyl-7,7a,8,8a-tetrahydroazireno[2,3-c]imidazo[4,5,1-ij]quinolin-5(4H)-one

Chemical Property of 13CD₃-(7aS,8aR)-4-benzyl-8-methyl-7,7a,8,8a-tetrahydroazireno[2,3-c]imidazo[4,5,1-ij]quinolin-5(4H)-one

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Technology Process of 13CD₃-(7aS,8aR)-4-benzyl-8-methyl-7,7a,8,8a-tetrahydroazireno[2,3-c]imidazo[4,5,1-ij]quinolin-5(4H)-one

There total 2 articles about 13CD₃-(7aS,8aR)-4-benzyl-8-methyl-7,7a,8,8a-tetrahydroazireno[2,3-c]imidazo[4,5,1-ij]quinolin-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

13CD3-(5R,6R)-1-benzyl-5-hydroxy-6-(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (845612-96-6) → 13CD3-(7aS,8aR)-4-benzyl-8-methyl-7,7a,8,8a-tetrahydroazireno[2,3-c]imidazo[4,5,1-ij]quinolin-5(4H)-one (845612-99-9)

Guidance literature:

13CD₃-(5R,6R)-1-benzyl-5-hydroxy-6-(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one; With n-butyllithium; In tetrahydrofuran; hexane; at -25 ℃; for 0.25h;

With benzenesulfonyl chloride; In tetrahydrofuran; hexane; at -25 - 20 ℃; for 2h;

DOI:10.1002/jlcr.848

Reference yield:

(5S,6S)-1-benzyl-5-bromo-2-oxo-1,2,5,6-tetrahydro-4H-imidazo[4,5,1-ij]quinolin-6-yl (2R)-2-(6-methoxy-2-naphthyl)propanoate → 13CD3-(7aS,8aR)-4-benzyl-8-methyl-7,7a,8,8a-tetrahydroazireno[2,3-c]imidazo[4,5,1-ij]quinolin-5(4H)-one (845612-99-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 89 percent / acetonitrile; H₂O / 72 h / 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.25 h / -25 °C

2.2: 55 percent / benzenesulfonyl chloride / hexane; tetrahydrofuran / 2 h / -25 - 20 °C

With n-butyllithium; In tetrahydrofuran; hexane; water; acetonitrile;

DOI:10.1002/jlcr.848

upstream raw materials:

13CD₃-(5R,6R)-1-benzyl-5-hydroxy-6-(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one

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