(2S,4R,6R,8R,10R)-N-[(1R,2R)-2-hydroxy-1-methyl-2-phenylethyl]-N,2,4,6,8,10-hexamethyldodecanamide

Base Information

Chemical Name:(2S,4R,6R,8R,10R)-N-[(1R,2R)-2-hydroxy-1-methyl-2-phenylethyl]-N,2,4,6,8,10-hexamethyldodecanamide
CAS No.:1326531-19-4
Molecular Formula:C₂₇H₄₇NO₂
Molecular Weight:417.676
Hs Code.:

Synonyms:(2S,4R,6R,8R,10R)-N-[(1R,2R)-2-hydroxy-1-methyl-2-phenylethyl]-N,2,4,6,8,10-hexamethyldodecanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4R,6R,8R,10R)-N-[(1R,2R)-2-hydroxy-1-methyl-2-phenylethyl]-N,2,4,6,8,10-hexamethyldodecanamide

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Technology Process of (2S,4R,6R,8R,10R)-N-[(1R,2R)-2-hydroxy-1-methyl-2-phenylethyl]-N,2,4,6,8,10-hexamethyldodecanamide

There total 3 articles about (2S,4R,6R,8R,10R)-N-[(1R,2R)-2-hydroxy-1-methyl-2-phenylethyl]-N,2,4,6,8,10-hexamethyldodecanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1326531-14-9
(2R,4R,6R,8R)-1-iodo-2,4,6,8-tetramethyldecane

: 192060-67-6
(1R,2R)-(-)-pseudoephedrinepropionamide

: 1326531-19-4
(2S,4R,6R,8R,10R)-N-[(1R,2R)-2-hydroxy-1-methyl-2-phenylethyl]-N,2,4,6,8,10-hexamethyldodecanamide

Guidance literature:: (1R,2R)-(-)-pseudoephedrinepropionamide; With lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1.33333h;

(2R,4R,6R,8R)-1-iodo-2,4,6,8-tetramethyldecane; In tetrahydrofuran; hexane; at 0 ℃; for 60h; optical yield given as %de; diastereoselective reaction;
DOI:10.1002/ejoc.201100412

Reference yield:

: 139632-56-7
(2R,4R,6R,8R)-2,4,6,8-tetramethyldecyl alcohol

: 1326531-19-4
(2S,4R,6R,8R,10R)-N-[(1R,2R)-2-hydroxy-1-methyl-2-phenylethyl]-N,2,4,6,8,10-hexamethyldodecanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 5.08 h / 0 - 20 °C

2.1: lithium chloride; lithium diisopropyl amide / tetrahydrofuran; hexane / 1.33 h / -78 - 20 °C

2.2: 60 h / 0 °C

With 1H-imidazole; iodine; triphenylphosphine; lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; 1.1: Appel reaction;
DOI:10.1002/ejoc.201100412

Reference yield:

: 2490-56-4
methyl (2R,4R,6R,8R)-2,4,6,8-tetramethyldecanoate

: 1326531-19-4
(2S,4R,6R,8R,10R)-N-[(1R,2R)-2-hydroxy-1-methyl-2-phenylethyl]-N,2,4,6,8,10-hexamethyldodecanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride / hexane; toluene / 2 h / -78 - -50 °C

2.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 5.08 h / 0 - 20 °C

3.1: lithium chloride; lithium diisopropyl amide / tetrahydrofuran; hexane / 1.33 h / -78 - 20 °C

3.2: 60 h / 0 °C

With 1H-imidazole; iodine; diisobutylaluminium hydride; triphenylphosphine; lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; toluene; 2.1: Appel reaction;
DOI:10.1002/ejoc.201100412