(βR)-N-[6-chloro-2-[(3S)-3-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]amino]-1-pyrrolidinyl]-5-quinolinyl]-β-methyl-benzenepropanamide

Base Information

Chemical Name:(βR)-N-[6-chloro-2-[(3S)-3-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]amino]-1-pyrrolidinyl]-5-quinolinyl]-β-methyl-benzenepropanamide
CAS No.:836612-32-9
Molecular Formula:C₃₁H₄₃ClN₄O₂Si
Molecular Weight:567.247
Hs Code.:

Synonyms:(βR)-N-[6-chloro-2-[(3S)-3-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]amino]-1-pyrrolidinyl]-5-quinolinyl]-β-methyl-benzenepropanamide

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Chemical Property of (βR)-N-[6-chloro-2-[(3S)-3-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]amino]-1-pyrrolidinyl]-5-quinolinyl]-β-methyl-benzenepropanamide

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Technology Process of (βR)-N-[6-chloro-2-[(3S)-3-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]amino]-1-pyrrolidinyl]-5-quinolinyl]-β-methyl-benzenepropanamide

There total 5 articles about (βR)-N-[6-chloro-2-[(3S)-3-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]amino]-1-pyrrolidinyl]-5-quinolinyl]-β-methyl-benzenepropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (βR)-N-[2-[(3S)-3-amino-1-pyrrolidinyl]-6-chloro-5-quinolinyl]-β-methyl-benzenepropanamide

: 102191-92-4
tert-butyldimethylsiloxyacetaldehyde

: 836612-32-9
(βR)-N-[6-chloro-2-[(3S)-3-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]amino]-1-pyrrolidinyl]-5-quinolinyl]-β-methyl-benzenepropanamide

Guidance literature:: (βR)-N-[2-[(3S)-3-amino-1-pyrrolidinyl]-6-chloro-5-quinolinyl]-β-methyl-benzenepropanamide; tert-butyldimethylsiloxyacetaldehyde; In methanol; at 20 ℃; for 6h; Molecular sieve;

With sodium tris(acetoxy)borohydride; In methanol; for 16h;

Reference yield:

: 836612-26-1
(βR)-N-(2,6-dichloro-5-quinolinyl)-β-methyl-benzenepropanamide

: 836612-32-9
(βR)-N-[6-chloro-2-[(3S)-3-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]amino]-1-pyrrolidinyl]-5-quinolinyl]-β-methyl-benzenepropanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / acetonitrile / 1 h / 100 °C / Microwave irradiation

2.1: methanol / 6 h / 20 °C / Molecular sieve

2.2: 16 h

With triethylamine; In methanol; acetonitrile;

Reference yield:

: 607380-28-9
2,6-dichloro-5-aminoquinoline

: 836612-32-9
(βR)-N-[6-chloro-2-[(3S)-3-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]amino]-1-pyrrolidinyl]-5-quinolinyl]-β-methyl-benzenepropanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / 1-methyl-pyrrolidin-2-one / 5 h / 50 °C

2.1: triethylamine / acetonitrile / 1 h / 100 °C / Microwave irradiation

3.1: methanol / 6 h / 20 °C / Molecular sieve

3.2: 16 h

With dmap; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In 1-methyl-pyrrolidin-2-one; methanol; acetonitrile;