benzyl 1-((4R)-2-aza-7-(((2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonylguanidino))-4-(9H-9-fluorenylmethoxycarboxamido)-3-oxoheptan-1-yl)cyclohexanecarboxylate

Base Information

Chemical Name:benzyl 1-((4R)-2-aza-7-(((2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonylguanidino))-4-(9H-9-fluorenylmethoxycarboxamido)-3-oxoheptan-1-yl)cyclohexanecarboxylate
CAS No.:1413936-86-3
Molecular Formula:C₃₄H₄₉N₅O₆S
Molecular Weight:655.859
Hs Code.:

benzyl 1-((4R)-2-aza-7-(((2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonylguanidino))-4-(9H-9-fluorenylmethoxycarboxamido)-3-oxoheptan-1-yl)cyclohexanecarboxylate

Synonyms:benzyl 1-((4R)-2-aza-7-(((2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonylguanidino))-4-(9H-9-fluorenylmethoxycarboxamido)-3-oxoheptan-1-yl)cyclohexanecarboxylate

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Chemical Property of benzyl 1-((4R)-2-aza-7-(((2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonylguanidino))-4-(9H-9-fluorenylmethoxycarboxamido)-3-oxoheptan-1-yl)cyclohexanecarboxylate

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Technology Process of benzyl 1-((4R)-2-aza-7-(((2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonylguanidino))-4-(9H-9-fluorenylmethoxycarboxamido)-3-oxoheptan-1-yl)cyclohexanecarboxylate

There total 2 articles about benzyl 1-((4R)-2-aza-7-(((2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonylguanidino))-4-(9H-9-fluorenylmethoxycarboxamido)-3-oxoheptan-1-yl)cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1413936-85-2
benzyl 1-(((4R)-2-aza-7-((2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonylguanidino))-4-(9H-9-fluorenylmethoxycarboxamido)-3-oxoheptan)cyclohexanecarboxylate

: 1413936-86-3
benzyl 1-((4R)-2-aza-7-(((2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonylguanidino))-4-(9H-9-fluorenylmethoxycarboxamido)-3-oxoheptan-1-yl)cyclohexanecarboxylate

Guidance literature:: With piperidine; In acetonitrile; at 20 ℃; for 3h;
DOI:10.3762/bjoc.8.142

Reference yield:

: 187618-60-6
N-α-[(9H-fluoren-9-ylmethoxy)carbonyl]-N^G-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-D-arginine

: 1413936-86-3
benzyl 1-((4R)-2-aza-7-(((2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonylguanidino))-4-(9H-9-fluorenylmethoxycarboxamido)-3-oxoheptan-1-yl)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 16 h / 20 °C

2: piperidine / acetonitrile / 3 h / 20 °C

With piperidine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile;
DOI:10.3762/bjoc.8.142

Reference yield: 83.0%

: C₃₈H₄₆N₂O₇

: 1413936-86-3
benzyl 1-((4R)-2-aza-7-(((2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonylguanidino))-4-(9H-9-fluorenylmethoxycarboxamido)-3-oxoheptan-1-yl)cyclohexanecarboxylate

: benzyl 1-((4R,7R)-4-(3-[(2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonyl]guanidinopropyl)-10-((S)-2'-(3-methylbutoxy)-1,1'-binaphth-2-yloxy)-7-(4-(tert-butoxycarbonylamino)butyl)-2,5,8-triaza-3,6,9-trioxodecan-1-yl)cyclohexanecarboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 20 ℃; for 16h;
DOI:10.3762/bjoc.8.142