(2S,4R,6S)-2-(hydroxymethyl)-6-nonyltetrahydro-2H-pyran-4-ol

Base Information

• Chemical Name: (2S,4R,6S)-2-(hydroxymethyl)-6-nonyltetrahydro-2H-pyran-4-ol
• CAS No.: 1403815-49-5
• Molecular Formula: C₂₂H₃₆O₅S
• Molecular Weight: 412.591
• Mol file: 1403815-49-5.mol

Synonyms:(2S,4R,6S)-2-(hydroxymethyl)-6-nonyltetrahydro-2H-pyran-4-ol

Chemical Property of (2S,4R,6S)-2-(hydroxymethyl)-6-nonyltetrahydro-2H-pyran-4-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,4R,6S)-2-(hydroxymethyl)-6-nonyltetrahydro-2H-pyran-4-ol

There total 2 articles about (2S,4R,6S)-2-(hydroxymethyl)-6-nonyltetrahydro-2H-pyran-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(2S,4R,6S)-2-(hydroxymethyl)-6-nonyltetrahydro-2H-pyran-4-ol (1403815-40-6) + p-toluenesulfonyl chloride (98-59-9) → (2S,4R,6S)-2-(hydroxymethyl)-6-nonyltetrahydro-2H-pyran-4-ol (1403815-49-5)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 3h;

DOI:10.1016/j.tetlet.2012.08.027

Reference yield:

caprinaldehyde (112-31-2) → (2S,4R,6S)-2-(hydroxymethyl)-6-nonyltetrahydro-2H-pyran-4-ol (1403815-49-5)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid; potassium carbonate / methanol; dichloromethane / 3 h / 20 °C

2: triethylamine / dichloromethane / 3 h / 0 - 20 °C

With potassium carbonate; triethylamine; trifluoroacetic acid; In methanol; dichloromethane;

DOI:10.1016/j.tetlet.2012.08.027

Reference yield: 90.0%

(2S,4R,6S)-2-(hydroxymethyl)-6-nonyltetrahydro-2H-pyran-4-ol (1403815-49-5) + chloromethyl methyl ether (107-30-2) → ((2S,4R,6S)-4-(methoxymethoxy)-6-nonyltetrahydro-2H-pyran-2-yl)methyl 4-methylbenzenesulfonate (1403815-41-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; at 0 - 20 ℃; for 2h;

DOI:10.1016/j.tetlet.2012.08.027

upstream raw materials:

caprinaldehyde

(2S,4R,6S)-2-(hydroxymethyl)-6-nonyltetrahydro-2H-pyran-4-ol

p-toluenesulfonyl chloride

Downstream raw materials:

((2S,4R,6S)-4-(methoxymethoxy)-6-nonyltetrahydro-2H-pyran-2-yl)methyl 4-methylbenzenesulfonate