N-cycloheptyl-5-(4-methoxyphenyl)-1-(4-fluorobenzyl)-pyridin-2(1H)-on-3-carboxamide

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Chemical Name:N-cycloheptyl-5-(4-methoxyphenyl)-1-(4-fluorobenzyl)-pyridin-2(1H)-on-3-carboxamide
CAS No.:1579273-62-3
Molecular Formula:C₂₇H₂₉FN₂O₃
Molecular Weight:448.537
Hs Code.:

Synonyms:N-cycloheptyl-5-(4-methoxyphenyl)-1-(4-fluorobenzyl)-pyridin-2(1H)-on-3-carboxamide

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Chemical Property of N-cycloheptyl-5-(4-methoxyphenyl)-1-(4-fluorobenzyl)-pyridin-2(1H)-on-3-carboxamide

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Technology Process of N-cycloheptyl-5-(4-methoxyphenyl)-1-(4-fluorobenzyl)-pyridin-2(1H)-on-3-carboxamide

There total 5 articles about N-cycloheptyl-5-(4-methoxyphenyl)-1-(4-fluorobenzyl)-pyridin-2(1H)-on-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1579273-73-6
N-cycloheptyl-5-(4-methoxyphenyl)-pyridin-2(1H)-on-3-carboxamide

: 352-11-4
1-chloromethyl-4-fluorobenzene

: 1579273-62-3
N-cycloheptyl-5-(4-methoxyphenyl)-1-(4-fluorobenzyl)-pyridin-2(1H)-on-3-carboxamide

Guidance literature:: N-cycloheptyl-5-(4-methoxyphenyl)-pyridin-2(1H)-on-3-carboxamide; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

1-chloromethyl-4-fluorobenzene; In N,N-dimethyl-formamide; for 24h;
DOI:10.1016/j.ejmech.2013.10.070

Reference yield:

: 1031203-87-8
N-cycloheptyl-pyridin-2(1H)-on-3-carboxamide

: 1579273-62-3
N-cycloheptyl-5-(4-methoxyphenyl)-1-(4-fluorobenzyl)-pyridin-2(1H)-on-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid; sodium acetate; bromine / 8 h / Reflux

2.1: triphenylphosphine; sodium carbonate; palladium diacetate / 1,4-dioxane; methanol / 0.25 h / 150 °C / 5171.62 Torr / Microwave irradiation; Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C

3.2: 24 h

With bromine; sodium acetate; palladium diacetate; sodium hydride; sodium carbonate; acetic acid; triphenylphosphine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; 2.1: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2013.10.070

Reference yield:

: 5452-35-7
cycloheptanamine

: 1579273-62-3
N-cycloheptyl-5-(4-methoxyphenyl)-1-(4-fluorobenzyl)-pyridin-2(1H)-on-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 48 h / 150 °C

2.1: acetic acid; sodium acetate; bromine / 8 h / Reflux

3.1: triphenylphosphine; sodium carbonate; palladium diacetate / 1,4-dioxane; methanol / 0.25 h / 150 °C / 5171.62 Torr / Microwave irradiation; Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C

4.2: 24 h

With bromine; sodium acetate; palladium diacetate; sodium hydride; sodium carbonate; acetic acid; triphenylphosphine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; 3.1: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2013.10.070