5-[((2S,4aR,6S,7R,8R,8aR)-8-Hydroxy-6-methylsulfanyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ylamino)-methylene]-1,3-dimethyl-pyrimidine-2,4,6-trione

Base Information

Chemical Name:5-[((2S,4aR,6S,7R,8R,8aR)-8-Hydroxy-6-methylsulfanyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ylamino)-methylene]-1,3-dimethyl-pyrimidine-2,4,6-trione
CAS No.:350239-10-0
Molecular Formula:C₂₁H₂₅N₃O₇S
Molecular Weight:463.511
Hs Code.:

5-[((2S,4aR,6S,7R,8R,8aR)-8-Hydroxy-6-methylsulfanyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ylamino)-methylene]-1,3-dimethyl-pyrimidine-2,4,6-trione

Synonyms:5-[((2S,4aR,6S,7R,8R,8aR)-8-Hydroxy-6-methylsulfanyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ylamino)-methylene]-1,3-dimethyl-pyrimidine-2,4,6-trione

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Chemical Property of 5-[((2S,4aR,6S,7R,8R,8aR)-8-Hydroxy-6-methylsulfanyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ylamino)-methylene]-1,3-dimethyl-pyrimidine-2,4,6-trione

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Technology Process of 5-[((2S,4aR,6S,7R,8R,8aR)-8-Hydroxy-6-methylsulfanyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ylamino)-methylene]-1,3-dimethyl-pyrimidine-2,4,6-trione

There total 8 articles about 5-[((2S,4aR,6S,7R,8R,8aR)-8-Hydroxy-6-methylsulfanyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ylamino)-methylene]-1,3-dimethyl-pyrimidine-2,4,6-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1125-88-8
benzaldehyde dimethyl acetal

: 350239-08-6
5-[((2S,3R,4R,5R,6R)-4,5-Dihydroxy-6-hydroxymethyl-2-methylsulfanyl-tetrahydro-pyran-3-ylamino)-methylene]-1,3-dimethyl-pyrimidine-2,4,6-trione

: 350239-10-0
5-[((2S,4aR,6S,7R,8R,8aR)-8-Hydroxy-6-methylsulfanyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ylamino)-methylene]-1,3-dimethyl-pyrimidine-2,4,6-trione

Guidance literature:: With toluene-4-sulfonic acid; In acetonitrile;
DOI:10.1016/S0040-4039(01)00366-5

Reference yield:

: 769-42-6
1,3-dimethylbarbituric acid

: 350239-10-0
5-[((2S,4aR,6S,7R,8R,8aR)-8-Hydroxy-6-methylsulfanyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ylamino)-methylene]-1,3-dimethyl-pyrimidine-2,4,6-trione

Guidance literature:: Multi-step reaction with 8 steps

1.1: 67 percent / CHCl₃ / 2 h / 0 °C

2.1: sodium / methanol / 0.13 h

2.2: 85 percent / methanol / 0.01 h / 20 °C

3.1: 96 percent / pyridine

4.1: 92 percent / HBr; AcOH / CH₂Cl₂

5.1: 53 percent / NaHCO₃; tetrabutylammonium hydrogensulfate / ethyl acetate

6.1: MeONa / methanol

7.1: 92 percent / p-toluene sulphonic acid / acetonitrile

With pyridine; hydrogen bromide; sodium methylate; tetra(n-butyl)ammonium hydrogensulfate; sodium; sodium hydrogencarbonate; toluene-4-sulfonic acid; acetic acid; In methanol; dichloromethane; chloroform; ethyl acetate; acetonitrile;
DOI:10.1016/S0040-4039(01)00366-5

Reference yield:

: 35824-98-7
1,3-dimethyl-5-[(dimethylamino)methylidene]pyrimidine-2,4,6(1H,3H,5H)-trione

: 350239-10-0
5-[((2S,4aR,6S,7R,8R,8aR)-8-Hydroxy-6-methylsulfanyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ylamino)-methylene]-1,3-dimethyl-pyrimidine-2,4,6-trione

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium / methanol / 0.13 h

1.2: 85 percent / methanol / 0.01 h / 20 °C

2.1: 96 percent / pyridine

3.1: 92 percent / HBr; AcOH / CH₂Cl₂

4.1: 53 percent / NaHCO₃; tetrabutylammonium hydrogensulfate / ethyl acetate

5.1: MeONa / methanol

6.1: 92 percent / p-toluene sulphonic acid / acetonitrile

With pyridine; hydrogen bromide; sodium methylate; tetra(n-butyl)ammonium hydrogensulfate; sodium; sodium hydrogencarbonate; toluene-4-sulfonic acid; acetic acid; In methanol; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1016/S0040-4039(01)00366-5