1-cyclobutylmethyl-4-[4-(2-methylpyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carbonitrile

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Chemical Name:1-cyclobutylmethyl-4-[4-(2-methylpyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carbonitrile
CAS No.:1362702-70-2
Molecular Formula:C₂₃H₂₁N₃O₂
Molecular Weight:371.439
Hs Code.:

Synonyms:1-cyclobutylmethyl-4-[4-(2-methylpyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carbonitrile

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Chemical Property of 1-cyclobutylmethyl-4-[4-(2-methylpyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carbonitrile

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Technology Process of 1-cyclobutylmethyl-4-[4-(2-methylpyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carbonitrile

There total 6 articles about 1-cyclobutylmethyl-4-[4-(2-methylpyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 950201-75-9
4-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenoxy]-2-methylpyridine

: 1362702-98-4
4-bromo-1-cyclobutylmethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile

: 1362702-70-2
1-cyclobutylmethyl-4-[4-(2-methylpyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carbonitrile

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In 1,4-dioxane; water; at 150 ℃; for 0.166667h; Microwave irradiation;
DOI:10.1021/jm2016864

Reference yield:

: 1362703-02-3
1-cyclobutylmethyl-4-methoxy-2-oxo-1,2-dihydropyridine-3-carbonitrile

: 1362702-70-2
1-cyclobutylmethyl-4-[4-(2-methylpyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: water; sodium hydroxide / 100 °C

2: phosphorus(V) oxybromide / N,N-dimethyl-formamide / 3 h / 110 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,4-dioxane; water / 0.17 h / 150 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; sodium hydrogencarbonate; sodium hydroxide; phosphorus(V) oxybromide; In 1,4-dioxane; water; N,N-dimethyl-formamide; 3: Suzuki coupling;
DOI:10.1021/jm2016864

Reference yield:

: 21642-98-8
2-hydroxy-4-methoxypyridine-3-carbonitrile

: 1362702-70-2
1-cyclobutylmethyl-4-[4-(2-methylpyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / Reflux

2: water; sodium hydroxide / 100 °C

3: phosphorus(V) oxybromide / N,N-dimethyl-formamide / 3 h / 110 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,4-dioxane; water / 0.17 h / 150 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; sodium hydrogencarbonate; potassium carbonate; sodium hydroxide; phosphorus(V) oxybromide; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile; 4: Suzuki coupling;
DOI:10.1021/jm2016864