3-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-2,2-diphenyl-1-propanol

Base Information

• Chemical Name: 3-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-2,2-diphenyl-1-propanol
• CAS No.: 850607-59-9
• Molecular Formula: C₂₃H₂₉NO
• Molecular Weight: 335.489

Synonyms:3-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-2,2-diphenyl-1-propanol

Chemical Property of 3-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-2,2-diphenyl-1-propanol

Chemical Property:

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Technology Process of 3-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-2,2-diphenyl-1-propanol

There total 1 articles about 3-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-2,2-diphenyl-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

3-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-2,2-diphenylpropanoicacid (850607-56-6) → 3-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-2,2-diphenyl-1-propanol (850607-59-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 100 ℃; Microwave irradiation;

DOI:10.1016/j.bmcl.2009.07.006

Reference yield: 38.0%

methyl bromide (74-83-9) + 3-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-2,2-diphenyl-1-propanol (850607-59-9) → (3-endo)-3-(3-hydroxy-2,2-diphenylpropyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide (1182100-66-8)

Guidance literature:

In tert-butyl methyl ether; acetone; at 20 ℃; for 1h;

DOI:10.1021/jm900736e

Reference yield:

3-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-2,2-diphenyl-1-propanol (850607-59-9) → (3-endo)-3-(3-hydroxy-2,2-diphenylpropyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide (1182100-66-8)

Guidance literature:

With methyl bromide;

DOI:10.1016/j.bmcl.2009.07.006

upstream raw materials:

3-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-2,2-diphenylpropanoicacid

Downstream raw materials:

(3-endo)-3-(3-hydroxy-2,2-diphenylpropyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide

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