(E,Z)-3-bromo-4'-[[(3S)-1-tert-butoxycarbonyl-3-pyrrolidinyl]oxy]stilbene

Base Information

Chemical Name:(E,Z)-3-bromo-4'-[[(3S)-1-tert-butoxycarbonyl-3-pyrrolidinyl]oxy]stilbene
CAS No.:859140-02-6
Molecular Formula:C₂₃H₂₆BrNO₃
Molecular Weight:444.368
Hs Code.:

Synonyms:(E,Z)-3-bromo-4'-[[(3S)-1-tert-butoxycarbonyl-3-pyrrolidinyl]oxy]stilbene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E,Z)-3-bromo-4'-[[(3S)-1-tert-butoxycarbonyl-3-pyrrolidinyl]oxy]stilbene

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Technology Process of (E,Z)-3-bromo-4'-[[(3S)-1-tert-butoxycarbonyl-3-pyrrolidinyl]oxy]stilbene

There total 1 articles about (E,Z)-3-bromo-4'-[[(3S)-1-tert-butoxycarbonyl-3-pyrrolidinyl]oxy]stilbene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 95902-10-6
(3-bromobenzyl)(triphenyl)phosphonium bromide

: 150613-54-0
4-<<(3S)-1-(tert-butoxycarbonyl)-3-pyrrolidinyl>oxy>benzaldehyde

: 859140-02-6
(E,Z)-3-bromo-4'-[[(3S)-1-tert-butoxycarbonyl-3-pyrrolidinyl]oxy]stilbene

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; ethanol; at 20 ℃; for 18h;
DOI:10.1016/j.bmc.2005.04.006

Reference yield: 39.0%

: 859140-02-6
(E,Z)-3-bromo-4'-[[(3S)-1-tert-butoxycarbonyl-3-pyrrolidinyl]oxy]stilbene

: 93830-58-1
diethyl (pyridin-4-yl)borane

: 859140-03-7
(S)-3-{4-[(E)-2-(3-Pyridin-4-yl-phenyl)-vinyl]-phenoxy}-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With potassium hydroxide; tetrabutylammomium bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; for 28h; Heating;
DOI:10.1016/j.bmc.2005.04.006

Reference yield:

: 859140-02-6
(E,Z)-3-bromo-4'-[[(3S)-1-tert-butoxycarbonyl-3-pyrrolidinyl]oxy]stilbene

: 859140-04-8
4-[3-[2-[4-[[(3S)-1-tert-butoxycarbonyl-3-pyrrolidinyl]oxy]phenyl]ethyl]phenyl]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 39 percent / tetrabutylammonium bromide; potassium hydroxide / tetrakis(triphenylphosphine)palladium⁽⁰⁾ / tetrahydrofuran / 28 h / Heating

2: 82 percent / hydrogen / Pd/C / ethanol / 16 h / 20 °C

With potassium hydroxide; tetrabutylammomium bromide; hydrogen; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; 1: Suzuki-Miyaura coupling;
DOI:10.1016/j.bmc.2005.04.006