{(2R,6R)-6-[(E)-6-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-hex-1-enyl]-2-methoxy-5-methyl-3,6-dihydro-2H-pyran-2-yl}-acetic acid methyl ester

Base Information

Chemical Name:{(2R,6R)-6-[(E)-6-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-hex-1-enyl]-2-methoxy-5-methyl-3,6-dihydro-2H-pyran-2-yl}-acetic acid methyl ester
CAS No.:129117-45-9
Molecular Formula:C₃₃H₄₆O₅Si
Molecular Weight:550.811
Hs Code.:

Synonyms:{(2R,6R)-6-[(E)-6-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-hex-1-enyl]-2-methoxy-5-methyl-3,6-dihydro-2H-pyran-2-yl}-acetic acid methyl ester

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Chemical Property of {(2R,6R)-6-[(E)-6-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-hex-1-enyl]-2-methoxy-5-methyl-3,6-dihydro-2H-pyran-2-yl}-acetic acid methyl ester

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Technology Process of {(2R,6R)-6-[(E)-6-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-hex-1-enyl]-2-methoxy-5-methyl-3,6-dihydro-2H-pyran-2-yl}-acetic acid methyl ester

There total 11 articles about {(2R,6R)-6-[(E)-6-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-hex-1-enyl]-2-methoxy-5-methyl-3,6-dihydro-2H-pyran-2-yl}-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 129117-43-7
{(2R,4R,5R,6S)-6-[(E)-6-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-hex-1-enyl]-4-hydroxy-2-methoxy-5-methyl-tetrahydro-pyran-2-yl}-acetic acid methyl ester

: 129117-45-9
{(2R,6R)-6-[(E)-6-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-hex-1-enyl]-2-methoxy-5-methyl-3,6-dihydro-2H-pyran-2-yl}-acetic acid methyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In toluene; at 80 ℃;
DOI:10.1016/S0040-4039(00)88866-8

Reference yield:

: 74844-86-3
(E)-7-hydroxy-2-methyl-hept-2-enoic acid ethyl ester

: 129117-45-9
{(2R,6R)-6-[(E)-6-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-hex-1-enyl]-2-methoxy-5-methyl-3,6-dihydro-2H-pyran-2-yl}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: imidazole

2: DIBAH

3: PDC, Zeolite 3A

4: 69 percent / Bu₂BOTf, Pr₂NEt

5: PPTS

6: LiAlH₄

7: PDC, Zeolite 3A

8: 1) NaH, n-BuLi

9: 20 percent / PPTS / methanol

10: 62 percent / DEAD, PPh₃ / toluene / 80 °C

With 1H-imidazole; lithium aluminium tetrahydride; dipyridinium dichromate; n-butyllithium; dipropylethylamine; Zeolite 3A; di-n-butylboryl trifluoromethanesulfonate; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; triphenylphosphine; diethylazodicarboxylate; In methanol; toluene;
DOI:10.1016/S0040-4039(00)88866-8

Reference yield:

: 154873-62-8
(E)-7-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-hept-2-en-1-ol

: 129117-45-9
{(2R,6R)-6-[(E)-6-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-hex-1-enyl]-2-methoxy-5-methyl-3,6-dihydro-2H-pyran-2-yl}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: PDC, Zeolite 3A

2: 69 percent / Bu₂BOTf, Pr₂NEt

3: PPTS

4: LiAlH₄

5: PDC, Zeolite 3A

6: 1) NaH, n-BuLi

7: 20 percent / PPTS / methanol

8: 62 percent / DEAD, PPh₃ / toluene / 80 °C

With lithium aluminium tetrahydride; dipyridinium dichromate; n-butyllithium; dipropylethylamine; Zeolite 3A; di-n-butylboryl trifluoromethanesulfonate; pyridinium p-toluenesulfonate; sodium hydride; triphenylphosphine; diethylazodicarboxylate; In methanol; toluene;
DOI:10.1016/S0040-4039(00)88866-8