(2S,3S,6R)-6-[(1S)-1-hydroxyethyl]-3-benzyloxymethyl-3,6-dihydro-2H-pyran-2-carboxylic acid 2,2,2-trichloroethyl ester

Base Information

Chemical Name:(2S,3S,6R)-6-[(1S)-1-hydroxyethyl]-3-benzyloxymethyl-3,6-dihydro-2H-pyran-2-carboxylic acid 2,2,2-trichloroethyl ester
CAS No.:264132-42-5
Molecular Formula:C₁₈H₂₁Cl₃O₅
Molecular Weight:423.721
Hs Code.:

Synonyms:(2S,3S,6R)-6-[(1S)-1-hydroxyethyl]-3-benzyloxymethyl-3,6-dihydro-2H-pyran-2-carboxylic acid 2,2,2-trichloroethyl ester

Suppliers and Price of (2S,3S,6R)-6-[(1S)-1-hydroxyethyl]-3-benzyloxymethyl-3,6-dihydro-2H-pyran-2-carboxylic acid 2,2,2-trichloroethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3S,6R)-6-[(1S)-1-hydroxyethyl]-3-benzyloxymethyl-3,6-dihydro-2H-pyran-2-carboxylic acid 2,2,2-trichloroethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3S,6R)-6-[(1S)-1-hydroxyethyl]-3-benzyloxymethyl-3,6-dihydro-2H-pyran-2-carboxylic acid 2,2,2-trichloroethyl ester

There total 4 articles about (2S,3S,6R)-6-[(1S)-1-hydroxyethyl]-3-benzyloxymethyl-3,6-dihydro-2H-pyran-2-carboxylic acid 2,2,2-trichloroethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 264132-41-4
(2S,3S,6R)-6-[(1S)-1-p-methoxybenzyloxymethoxyethyl]-3-benzyloxymethyl-3,6-dihydro-2H-pyran-2-carboxylic acid 2,2,2-trichloroethyl ester

: 264132-42-5
(2S,3S,6R)-6-[(1S)-1-hydroxyethyl]-3-benzyloxymethyl-3,6-dihydro-2H-pyran-2-carboxylic acid 2,2,2-trichloroethyl ester

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water; for 1h;
DOI:10.1021/jo991681n

Reference yield:

: 264132-38-9
(1R,2S)-[2-(p-methoxybenzyloxymethoxy)-1-ethenylpropoxy]acetic acid tert-butyl ester

: 264132-42-5
(2S,3S,6R)-6-[(1S)-1-hydroxyethyl]-3-benzyloxymethyl-3,6-dihydro-2H-pyran-2-carboxylic acid 2,2,2-trichloroethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: ozone; Ph₃P / CH₂Cl₂ / -78 °C

1.2: 65 percent / CuI; n-Bu₃P; BuLi / diethyl ether; tetrahydrofuran; hexane / 2 h / -78 °C

2.1: trifluoroacetic acid / benzene / 0.5 h / Heating

2.2: LiHMDS; Me₃SiCl; Et₃N / tetrahydrofuran / -78 °C

2.3: 89 percent / HCl / H₂O / pH 2

3.1: 92 percent / DMAP; DIC; TFA / CH₂Cl₂ / 40 °C

4.1: 82 percent / DDQ / H₂O; CH₂Cl₂ / 1 h

With dmap; ozone; dacarbazine; triphenylphosphine; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water; benzene; 1.1: Oxidation / 1.2: Addition / 2.1: Cyclization / 2.2: Rearrangement / 2.3: Hydrolysis / 3.1: Esterification / 4.1: Hydrolysis;
DOI:10.1021/jo991681n

Reference yield:

: 264132-40-3
(2S,3S,6R)-6-[(1S)-1-p-methoxybenzyloxymethoxyethyl]-3-benzyloxymethyl-3,6-dihydro-2H-pyran-2-carboxylic acid

: 264132-42-5
(2S,3S,6R)-6-[(1S)-1-hydroxyethyl]-3-benzyloxymethyl-3,6-dihydro-2H-pyran-2-carboxylic acid 2,2,2-trichloroethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / DMAP; DIC; TFA / CH₂Cl₂ / 40 °C

2: 82 percent / DDQ / H₂O; CH₂Cl₂ / 1 h

With dmap; dacarbazine; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water; 1: Esterification / 2: Hydrolysis;
DOI:10.1021/jo991681n