Technology Process of 14-epi-2β-methyl-1α,25-dihydroxy-19-norprevitamin D3
There total 10 articles about 14-epi-2β-methyl-1α,25-dihydroxy-19-norprevitamin D3 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
quinoline; hydrogen;
In
methanol; dichloromethane;
at 20 ℃;
for 0.416667h;
DOI:10.1021/ja201481j
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / -78 - 20 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: copper(l) iodide; bis(acetato)bis(triphenylphosphine)palladium(0); diethylamine / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
4.1: Wilkinson's catalyst; hydrogen / dichloromethane; benzene / 1 h / 20 °C
5.1: quinoline; hydrogen / methanol; dichloromethane / 0.42 h / 20 °C
With
quinoline; copper(l) iodide; Wilkinson's catalyst; bis(acetato)bis(triphenylphosphine)palladium(0); tetrabutyl ammonium fluoride; hydrogen; diethylamine; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; benzene;
2.1: Sonogashira coupling reaction;
DOI:10.1021/ja201481j
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: tetra-n-propylammonium perruthenate.; 4-methylmorpholine N-oxide / dichloromethane / 0 - 20 °C / Molecular sieve; Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; diethyl ether; hexane / 0.5 h / -78 °C / Inert atmosphere
2.2: 2.25 h / -78 - 0 °C / Inert atmosphere
3.1: copper(l) iodide; bis(acetato)bis(triphenylphosphine)palladium(0); diethylamine / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
5.1: Wilkinson's catalyst; hydrogen / dichloromethane; benzene / 1 h / 20 °C
6.1: quinoline; hydrogen / methanol; dichloromethane / 0.42 h / 20 °C
With
quinoline; copper(l) iodide; Wilkinson's catalyst; n-butyllithium; bis(acetato)bis(triphenylphosphine)palladium(0); tetra-n-propylammonium perruthenate.; tetrabutyl ammonium fluoride; hydrogen; 4-methylmorpholine N-oxide; diethylamine;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; benzene;
3.1: Sonogashira coupling reaction;
DOI:10.1021/ja201481j
