2-[6-[[4-(tert-butyl-dimethyl-silanyloxy)-6-(4-chloro-butyl)-2-methoxy-5-methyl-tetrahydro-pyran-2-yl]-(4-methoxy-benzyloxy)-methyl]-3,4-bis-(4-methoxy-benzyloxy)-5-methyl-tetrahydro-pyran-2-yl]-N-methoxy-N-methyl-acetamide

Base Information

Chemical Name:2-[6-[[4-(tert-butyl-dimethyl-silanyloxy)-6-(4-chloro-butyl)-2-methoxy-5-methyl-tetrahydro-pyran-2-yl]-(4-methoxy-benzyloxy)-methyl]-3,4-bis-(4-methoxy-benzyloxy)-5-methyl-tetrahydro-pyran-2-yl]-N-methoxy-N-methyl-acetamide
CAS No.:866783-45-1
Molecular Formula:C₅₂H₇₈ClNO₁₂Si
Molecular Weight:972.729
Hs Code.:

2-[6-[[4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-6-(4-chloro-butyl)-2-methoxy-5-methyl-tetrahydro-pyran-2-yl]-(4-methoxy-benzyloxy)-methyl]-3,4-bis-(4-methoxy-benzyloxy)-5-methyl-tetrahydro-pyran-2-yl]-<i>N</i>-methoxy-<i>N</i>-methyl-acetamide

Synonyms:2-[6-[[4-(tert-butyl-dimethyl-silanyloxy)-6-(4-chloro-butyl)-2-methoxy-5-methyl-tetrahydro-pyran-2-yl]-(4-methoxy-benzyloxy)-methyl]-3,4-bis-(4-methoxy-benzyloxy)-5-methyl-tetrahydro-pyran-2-yl]-N-methoxy-N-methyl-acetamide

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Chemical Property of 2-[6-[[4-(tert-butyl-dimethyl-silanyloxy)-6-(4-chloro-butyl)-2-methoxy-5-methyl-tetrahydro-pyran-2-yl]-(4-methoxy-benzyloxy)-methyl]-3,4-bis-(4-methoxy-benzyloxy)-5-methyl-tetrahydro-pyran-2-yl]-N-methoxy-N-methyl-acetamide

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Technology Process of 2-[6-[[4-(tert-butyl-dimethyl-silanyloxy)-6-(4-chloro-butyl)-2-methoxy-5-methyl-tetrahydro-pyran-2-yl]-(4-methoxy-benzyloxy)-methyl]-3,4-bis-(4-methoxy-benzyloxy)-5-methyl-tetrahydro-pyran-2-yl]-N-methoxy-N-methyl-acetamide

There total 41 articles about 2-[6-[[4-(tert-butyl-dimethyl-silanyloxy)-6-(4-chloro-butyl)-2-methoxy-5-methyl-tetrahydro-pyran-2-yl]-(4-methoxy-benzyloxy)-methyl]-3,4-bis-(4-methoxy-benzyloxy)-5-methyl-tetrahydro-pyran-2-yl]-N-methoxy-N-methyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 866783-28-0
2-[(2R,3R,4R,5R,6R)-6-[(S)-[(2R,4S,5R,6R)-6-(4-Chloro-butyl)-4-hydroxy-2-methoxy-5-methyl-tetrahydro-pyran-2-yl]-(4-methoxy-benzyloxy)-methyl]-3,4-bis-(4-methoxy-benzyloxy)-5-methyl-tetrahydro-pyran-2-yl]-N-methoxy-N-methyl-acetamide

: 69739-34-0
t-butyldimethylsiyl triflate

: 866783-45-1
2-[6-[[4-(tert-butyl-dimethyl-silanyloxy)-6-(4-chloro-butyl)-2-methoxy-5-methyl-tetrahydro-pyran-2-yl]-(4-methoxy-benzyloxy)-methyl]-3,4-bis-(4-methoxy-benzyloxy)-5-methyl-tetrahydro-pyran-2-yl]-N-methoxy-N-methyl-acetamide

Guidance literature:: With 2,6-dimethylpyridine; In tetrahydrofuran; at -78 ℃;
DOI:10.1039/c3sc50304f

Reference yield:

: 866783-43-9
(S)-3-((2S,3R)-7-Chloro-3-hydroxy-2-methyl-heptanoyl)-4-isopropyl-oxazolidin-2-one

: 866783-45-1
2-[6-[[4-(tert-butyl-dimethyl-silanyloxy)-6-(4-chloro-butyl)-2-methoxy-5-methyl-tetrahydro-pyran-2-yl]-(4-methoxy-benzyloxy)-methyl]-3,4-bis-(4-methoxy-benzyloxy)-5-methyl-tetrahydro-pyran-2-yl]-N-methoxy-N-methyl-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: 78 percent / imidazole / dimethylformamide / 2 h / 20 °C

2: 80 percent / n-BuLi / tetrahydrofuran / 0.5 h / 0 °C

3: 98 percent / Et₃SiH / Pd/C / CH₂Cl₂ / 0.17 h / 20 °C

4: 3 h / -78 - 0 °C

5: 89 percent / PPTS; TMOF / tetrahydrofuran / 0.33 h / 20 °C

6: 86 percent / 2,6-lutidine / tetrahydrofuran / 0.33 h / -78 °C

With 1H-imidazole; 2,6-dimethylpyridine; triethylsilane; n-butyllithium; pyridinium p-toluenesulfonate; trimethyl orthoformate; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-2005-871960

Reference yield:

: 866783-26-8
(2S,3R)-7-Chloro-2-methyl-3-triethylsilanyloxy-heptanethioic acid S-ethyl ester

: 866783-45-1
2-[6-[[4-(tert-butyl-dimethyl-silanyloxy)-6-(4-chloro-butyl)-2-methoxy-5-methyl-tetrahydro-pyran-2-yl]-(4-methoxy-benzyloxy)-methyl]-3,4-bis-(4-methoxy-benzyloxy)-5-methyl-tetrahydro-pyran-2-yl]-N-methoxy-N-methyl-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / Et₃SiH / Pd/C / CH₂Cl₂ / 0.17 h / 20 °C

2: 3 h / -78 - 0 °C

3: 89 percent / PPTS; TMOF / tetrahydrofuran / 0.33 h / 20 °C

4: 86 percent / 2,6-lutidine / tetrahydrofuran / 0.33 h / -78 °C

With 2,6-dimethylpyridine; triethylsilane; pyridinium p-toluenesulfonate; trimethyl orthoformate; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;
DOI:10.1055/s-2005-871960