BOC-PHE-PRO-OH

Base Information

• Chemical Name: BOC-PHE-PRO-OH
• CAS No.: 23420-32-8
• Molecular Formula: C19H26 N2 O5
• Molecular Weight: 362.426
• Mol file: 23420-32-8.mol

Synonyms:L-Proline,1-[N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl]-; Proline,1-(N-carboxy-3-phenyl-L-alanyl)-, N-tert-butyl ester, L- (8CI); Boc-Phe-Pro-OH;tert-Butoxycarbonyl-L-phenylalanyl-L-proline

Chemical Property of BOC-PHE-PRO-OH

Chemical Property:

• Vapor Pressure: 5.63E-15mmHg at 25°C
• Melting Point: 155-157 °C(Solv: methanol (67-56-1); ethyl ether (60-29-7))
• Refractive Index: 1.554
• Boiling Point: 594.4°C at 760 mmHg
• PKA: 3.51±0.20(Predicted)
• Flash Point: 313.3°C
• PSA: 95.94000
• Density: 1.225g/cm³
• LogP: 2.52680
• Storage Temp.: -15°C

Purity/Quality:

97% ^*data from raw suppliers

Boc-Phe-Pro-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-PHE-PRO-OH

There total 15 articles about BOC-PHE-PRO-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

t-butyloxycarbonyl-L-phenylalanyl-L-proline methyl ester (38017-89-9) → N-tert-butoxycarbonyl-L-phenylalanyl-L-proline (23420-32-8)

Guidance literature:

With sodium hydroxide; In methanol; for 2h; Ambient temperature;

DOI:10.1246/bcsj.69.3607

Reference yield: 94.3%

Boc-Phe-ONSu (3674-06-4) + L-proline (147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → N-tert-butoxycarbonyl-L-phenylalanyl-L-proline (23420-32-8)

Guidance literature:

L-proline; With N,O-bis-(trimethylsilyl)-acetamide; In dichloromethane; at 23 ℃; for 8h; Inert atmosphere;

Boc-Phe-ONSu; In dichloromethane; at 23 ℃; Solvent; Time; Inert atmosphere;

DOI:10.1016/j.cclet.2015.11.012

Reference yield: 90.0%

→ N-tert-butoxycarbonyl-L-phenylalanyl-L-proline (23420-32-8)

Guidance literature:

upstream raw materials:

t-butyloxycarbonyl-L-phenylalanyl-L-proline methyl ester

N-t-butoxycarbonyl-L-phenylalanine 4-nitrophenyl ester

L-proline

N-tert-butoxycarbonyl-L-phenylalanine

Downstream raw materials:

2-(1-{2-[2-(2-{[1-(2-tert-butoxycarbonylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-pentanoylamino)-3-hydroxy-butyrylamino]-3-phenyl-propionyl}-pyrrolidin-2-yl)-thiazole-4-carboxylic acid methyl ester

2-(1-{2-[2-(2-{[1-(2-tert-butoxycarbonylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-pentanoylamino)-3-hydroxy-butyrylamino]-3-phenyl-propionyl}-pyrrolidin-2-yl)-thiazole-4-carboxylic acid methyl ester

C₃₈H₄₆N₄O₈

(S)-1-((S)-2-carboxypyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-aminium chloride