3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-N-(5-(4-dodecylphenyl)-1,3,4-thiadiazol-2-yl)-2,2-dimethylcyclopropanecarboxamide

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Chemical Name:3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-N-(5-(4-dodecylphenyl)-1,3,4-thiadiazol-2-yl)-2,2-dimethylcyclopropanecarboxamide
CAS No.:1369885-82-4
Molecular Formula:C₂₉H₃₉ClF₃N₃OS
Molecular Weight:570.162
Hs Code.:

Synonyms:3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-N-(5-(4-dodecylphenyl)-1,3,4-thiadiazol-2-yl)-2,2-dimethylcyclopropanecarboxamide

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Chemical Property of 3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-N-(5-(4-dodecylphenyl)-1,3,4-thiadiazol-2-yl)-2,2-dimethylcyclopropanecarboxamide

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Technology Process of 3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-N-(5-(4-dodecylphenyl)-1,3,4-thiadiazol-2-yl)-2,2-dimethylcyclopropanecarboxamide

There total 7 articles about 3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-N-(5-(4-dodecylphenyl)-1,3,4-thiadiazol-2-yl)-2,2-dimethylcyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.4%

: 74609-46-4
3-(2-chloro-3,3,3-trifluoroprop-1-en-yl)-2,2-dimethylcyclopropanecarboxylic acid

: 1233091-82-1
5-(4-dodecylphenyl)-1,3,4-thiadiazol-2-amine

: 1369885-82-4
3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-N-(5-(4-dodecylphenyl)-1,3,4-thiadiazol-2-yl)-2,2-dimethylcyclopropanecarboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.3184/174751911X13230201951890

Reference yield:

: 6313-88-8
4-dodecylacetophenone

: 1369885-82-4
3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-N-(5-(4-dodecylphenyl)-1,3,4-thiadiazol-2-yl)-2,2-dimethylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hypobromide / tetrahydrofuran / 3 h / 0 - 5 °C / Reflux

2: trichlorophosphate / 4.5 h / 0 - 5 °C / Reflux

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

With sodium hypobromide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.3184/174751911X13230201951890

Reference yield:

: 17746-06-4
n-tridecanoyl chloride

: 1369885-82-4
3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-N-(5-(4-dodecylphenyl)-1,3,4-thiadiazol-2-yl)-2,2-dimethylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: aluminum (III) chloride / 3 h / Reflux; Cooling with ice

2.1: hydrazine hydrate / diethylene glycol / 2.5 h / Reflux

2.2: 4 h / Reflux

3.1: carbon disulfide / 50 °C

4.1: sodium hypobromide / tetrahydrofuran / 3 h / 0 - 5 °C / Reflux

5.1: trichlorophosphate / 4.5 h / 0 - 5 °C / Reflux

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

With carbon disulfide; aluminum (III) chloride; sodium hypobromide; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide; diethylene glycol; 1.1: Friedel Crafts acylation;
DOI:10.3184/174751911X13230201951890