N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-4-(1,4-dimethyl-1H-pyrazol-5-yl)-5-methyl-2-furancarboxamide

Base Information

Chemical Name:N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-4-(1,4-dimethyl-1H-pyrazol-5-yl)-5-methyl-2-furancarboxamide
CAS No.:1047627-43-9
Molecular Formula:C₂₁H₂₃F₃N₄O₂
Molecular Weight:420.434
Hs Code.:

Synonyms:N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-4-(1,4-dimethyl-1H-pyrazol-5-yl)-5-methyl-2-furancarboxamide

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Chemical Property of N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-4-(1,4-dimethyl-1H-pyrazol-5-yl)-5-methyl-2-furancarboxamide

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Technology Process of N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-4-(1,4-dimethyl-1H-pyrazol-5-yl)-5-methyl-2-furancarboxamide

There total 7 articles about N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-4-(1,4-dimethyl-1H-pyrazol-5-yl)-5-methyl-2-furancarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1047628-96-5
4-(1,4-dimethyl-1H-pyrazol-5-yl)-N-((1S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-5-methyl-2-furancarboxamide

: 1047627-43-9
N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-4-(1,4-dimethyl-1H-pyrazol-5-yl)-5-methyl-2-furancarboxamide

Guidance literature:: With hydrazine; In tetrahydrofuran; methanol; at 25 ℃; for 12h;

Reference yield:

: 2527-96-0
methyl 5-methyl-2-furancarboxylate

: 1047627-43-9
N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-4-(1,4-dimethyl-1H-pyrazol-5-yl)-5-methyl-2-furancarboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: aluminum (III) chloride; bromine / chloroform / 12 h / 0 - 20 °C

2.1: potassium carbonate / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 80 °C

3.1: N-Bromosuccinimide / tetrahydrofuran / 1 h / 70 °C

4.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 2 h / 110 °C

5.1: sodium hydroxide / tetrahydrofuran; water / 1 h / 70 °C

5.2: acid / pH 4

6.1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane / 1 h / 25 °C

7.1: hydrazine / tetrahydrofuran; methanol / 12 h / 25 °C

With aluminum (III) chloride; sodium hydroxide; N-Bromosuccinimide; bromine; potassium carbonate; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; hydrazine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide;

Reference yield:

: 1047628-84-1
methyl 5-methyl-4-(1-methyl-1H-pyrazol-5-yl)-2-furancarboxylate

: 1047627-43-9
N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-4-(1,4-dimethyl-1H-pyrazol-5-yl)-5-methyl-2-furancarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide / tetrahydrofuran / 1 h / 70 °C

2.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 2 h / 110 °C

3.1: sodium hydroxide / tetrahydrofuran; water / 1 h / 70 °C

3.2: acid / pH 4

4.1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane / 1 h / 25 °C

5.1: hydrazine / tetrahydrofuran; methanol / 12 h / 25 °C

With sodium hydroxide; N-Bromosuccinimide; potassium carbonate; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; hydrazine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;