(R)-(-)-1,2,3,4-Tetrahydro-1-naphthol

Base Information

• Chemical Name: (R)-(-)-1,2,3,4-Tetrahydro-1-naphthol
• CAS No.: 23357-45-1
• Molecular Formula: C10H12O
• Molecular Weight: 148.205
• European Community (EC) Number: 622-816-1
• Nikkaji Number: J330.336E
• ChEMBL ID: CHEMBL203428
• Mol file: 23357-45-1.mol

Synonyms:23357-45-1;(R)-(-)-1,2,3,4-Tetrahydro-1-naphthol;(R)-1,2,3,4-tetrahydronaphthalen-1-ol;(1R)-1,2,3,4-Tetrahydronaphthalen-1-ol;(R)-1-Tetralol;(R)-Tetralin-1-ol;(R)-1,2,3,4-Tetrahydro-1-naphthol;CHEMBL203428;(R)-(-)-alpha-Tetralol;(r)-tetralol;(-)-1,2,3,4-Tetrahydro-1-naphthol;5929-35-1;(R)-?Tetralol;MFCD00063005;24-Tetrahydro-1-naphthol;(R)-Tetrahydro-1-naphthol;SCHEMBL3596545;JAAJQSRLGAYGKZ-SNVBAGLBSA-N;(R)-1,2,3,4-Tetrahydronaphthol;BDBM50183616;AKOS013153128;AKOS015833097;AS-65542;(R)-1,2,3,4-Tetrahydro-1-naphthalenol;(R)-(+)-1,2,3,4-tetrahydro-1-naphthol;CS-0079970;T2359;(R)-1,2,3,4-Tetrahydro-1-hydroxynaphthalene;(R)-1-Naphthol, (R)-1,2,3,4-tetrahydro-;T72122;EN300-6487479;1-Naphthalenol, 1,2,3,4-tetrahydro-, (1R)-;A878269;(R)-(-)-1,2,3,4-Tetrahydro-1-naphthol, 99%;J-015080;(R)-(-)-1,2,3,4-Tetrahydro-1-naphthol, puriss., >=99.0% (sum of enantiomers, GC)

Chemical Property of (R)-(-)-1,2,3,4-Tetrahydro-1-naphthol

Chemical Property:

• Vapor Pressure: 0.00874mmHg at 25°C
• Melting Point: 37-39 °C
• Refractive Index: 1.584
• Boiling Point: 254.829 °C at 760 mmHg
• PKA: 14.33±0.20(Predicted)
• Flash Point: 99.904 °C
• PSA: 20.23000
• Density: 1.112 g/cm³
• LogP: 2.05630
• Storage Temp.: 0-10°C
• Solubility.: soluble in Methanol
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 148.088815002
• Heavy Atom Count: 11
• Complexity: 133

Purity/Quality:

97% ^*data from raw suppliers

(R)-(-)-1,2,3,4-Tetrahydro-1-naphthol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(C2=CC=CC=C2C1)O
• Isomeric SMILES: C1C[C@H](C2=CC=CC=C2C1)O
• Uses: (R)-(-)-1,2,3,4-Tetrahydro-1-naphthol is a pharmacceutical building block used in the synthesis of organic compounds such as GPR40 agonists acting as a novel insulin secretagogues with low risk of hypoglycemia.

Technology Process of (R)-(-)-1,2,3,4-Tetrahydro-1-naphthol

There total 49 articles about (R)-(-)-1,2,3,4-Tetrahydro-1-naphthol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3,4-dihydronaphthalene-1(2H)-one (529-34-0) → (R)-(-)-1,2,3,4-tetrahydro-1-naphthol (529-33-9,23357-45-1,53732-47-1,87248-51-9)

Guidance literature:

With 2-(ethylamino)pyridine; lithium aluminium tetrahydride; (-)-N-methylephedrine; In diethyl ether; at -78 ℃; for 3h;

Reference yield: 63.0%

tetralin (119-64-2) → (R)-1-tetralol (23357-45-1) + 3,4-dihydronaphthalene-1(2H)-one (529-34-0)

Guidance literature:

With Pseudomonas monteilii TA-5 cells; at 30 ℃; for 7h; pH=7.0; optical yield given as %ee; enantioselective reaction; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1016/j.tetasy.2009.04.006

Reference yield: 60.0%

1,2,3,4-Tetrahydro-1-naphthol (529-33-9) → (R)-1-tetralol (23357-45-1) + 3,4-dihydronaphthalene-1(2H)-one (529-34-0)

Guidance literature:

In water; at 25 ℃; for 72h; by Helminthosporium species;

upstream raw materials:

tetralin

1,2,3,4-Tetrahydro-1-naphthol

3,4-dihydronaphthalene-1(2H)-one

1,2-Dihydronaphthalene

Downstream raw materials:

(R)-tris(4-methoxyphenyl)((1,2,3,4-tetrahydronaphthalen-1-yl)-oxy)silane

(R)-((1,2,3,4-tetrahydronaphthalen-1-yl)oxy)tri-p-tolylsilane

(R)-tris(4-ethylphenyl)((1,2,3,4-tetrahydronaphthalen-1-yl)oxy)-silane

(R)-tris(4-isopropylphenyl)((1,2,3,4-tetrahydronaphthalen-1-yl)-oxy)silane