(E)-2-((4-benzhydrylpiperazin-1-yl)methyl)-3-(4-fluorophenyl)acrylonitrile

Base Information

Chemical Name:(E)-2-((4-benzhydrylpiperazin-1-yl)methyl)-3-(4-fluorophenyl)acrylonitrile
CAS No.:1527470-77-4
Molecular Formula:C₂₇H₂₆FN₃
Molecular Weight:411.522
Hs Code.:

Synonyms:(E)-2-((4-benzhydrylpiperazin-1-yl)methyl)-3-(4-fluorophenyl)acrylonitrile

Suppliers and Price of (E)-2-((4-benzhydrylpiperazin-1-yl)methyl)-3-(4-fluorophenyl)acrylonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-2-((4-benzhydrylpiperazin-1-yl)methyl)-3-(4-fluorophenyl)acrylonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-2-((4-benzhydrylpiperazin-1-yl)methyl)-3-(4-fluorophenyl)acrylonitrile

There total 6 articles about (E)-2-((4-benzhydrylpiperazin-1-yl)methyl)-3-(4-fluorophenyl)acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 841-77-0
diphenylmethylpiperazine

: 1527470-81-0
C₁₀H₇BrFN

: 1527470-77-4
(E)-2-((4-benzhydrylpiperazin-1-yl)methyl)-3-(4-fluorophenyl)acrylonitrile

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 6h;
DOI:10.1007/s00044-013-0895-7

Reference yield:

: 890051-61-3
3-(4-fluorophenyl)-3-hydroxy-2-methylenepropanenitrile

: 1527470-77-4
(E)-2-((4-benzhydrylpiperazin-1-yl)methyl)-3-(4-fluorophenyl)acrylonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen bromide; sulfuric acid / dichloromethane / 0 - 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C

With sulfuric acid; hydrogen bromide; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1007/s00044-013-0895-7

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 1527470-77-4
(E)-2-((4-benzhydrylpiperazin-1-yl)methyl)-3-(4-fluorophenyl)acrylonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 1,4-diaza-bicyclo[2.2.2]octane / neat (no solvent) / 20 °C

2: hydrogen bromide; sulfuric acid / dichloromethane / 0 - 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; sulfuric acid; hydrogen bromide; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1007/s00044-013-0895-7