3-{4-[(2-aminoethyl)amino]-1,2,5-oxadiazol-3-yl}-4-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5(4H)-one hydroiodide

Base Information

Chemical Name:3-{4-[(2-aminoethyl)amino]-1,2,5-oxadiazol-3-yl}-4-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5(4H)-one hydroiodide
CAS No.:1204670-05-2
Molecular Formula:C₁₃H₁₁F₃N₆O₃*HI
Molecular Weight:484.176
Hs Code.:

Synonyms:3-{4-[(2-aminoethyl)amino]-1,2,5-oxadiazol-3-yl}-4-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5(4H)-one hydroiodide

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Chemical Property of 3-{4-[(2-aminoethyl)amino]-1,2,5-oxadiazol-3-yl}-4-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5(4H)-one hydroiodide

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Technology Process of 3-{4-[(2-aminoethyl)amino]-1,2,5-oxadiazol-3-yl}-4-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5(4H)-one hydroiodide

There total 8 articles about 3-{4-[(2-aminoethyl)amino]-1,2,5-oxadiazol-3-yl}-4-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5(4H)-one hydroiodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1204670-04-1
3-{4-[(2-azidoethyl)amino]-1,2,5-oxadiazol-3-yl}-4-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5(4H)-one

: 1204670-05-2
3-{4-[(2-aminoethyl)amino]-1,2,5-oxadiazol-3-yl}-4-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5(4H)-one hydroiodide

Guidance literature:: With chloro-trimethyl-silane; sodium iodide; sodium thiosulfate; In methanol; water;

Reference yield:

: 1204670-03-0
2-[(4-{5-oxo-4-[3-(trifluoromethyl)phenyl]-4,5-dihydro-1,2,4-oxadiazol-3-yl}-1,2,5-oxadiazol-3-yl)amino]ethyl methanesulfonate

: 1204670-05-2
3-{4-[(2-aminoethyl)amino]-1,2,5-oxadiazol-3-yl}-4-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5(4H)-one hydroiodide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide / N,N-dimethyl-formamide / 6 h / 65 °C

2: sodium iodide; chloro-trimethyl-silane / methanol / 0.92 h

With chloro-trimethyl-silane; sodium azide; sodium iodide; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 1204670-01-8
3-{4-[(2-methoxyethyl)amino]-1,2,5-oxadiazol-3-yl}-4-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5(4H)-one

: 1204670-05-2
3-{4-[(2-aminoethyl)amino]-1,2,5-oxadiazol-3-yl}-4-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5(4H)-one hydroiodide

Guidance literature:: Multi-step reaction with 4 steps

1: boron tribromide / dichloromethane / 1.75 h / -78 - 20 °C / Inert atmosphere

2: triethylamine / ethyl acetate / 0.25 h

3: sodium azide / N,N-dimethyl-formamide / 6 h / 65 °C

4: sodium iodide; chloro-trimethyl-silane / methanol / 0.92 h

With chloro-trimethyl-silane; sodium azide; boron tribromide; triethylamine; sodium iodide; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;