2-methylpropane-1-sulfonic acid {4-[4-(3-nitrophenyl)piperazin-1-yl]butyl}amide

Base Information

• Chemical Name: 2-methylpropane-1-sulfonic acid {4-[4-(3-nitrophenyl)piperazin-1-yl]butyl}amide
• CAS No.: 896125-11-4
• Molecular Formula: C₁₈H₃₀N₄O₄S
• Molecular Weight: 398.527
• Mol file: 896125-11-4.mol

Synonyms:2-methylpropane-1-sulfonic acid {4-[4-(3-nitrophenyl)piperazin-1-yl]butyl}amide

Chemical Property of 2-methylpropane-1-sulfonic acid {4-[4-(3-nitrophenyl)piperazin-1-yl]butyl}amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methylpropane-1-sulfonic acid {4-[4-(3-nitrophenyl)piperazin-1-yl]butyl}amide

There total 5 articles about 2-methylpropane-1-sulfonic acid {4-[4-(3-nitrophenyl)piperazin-1-yl]butyl}amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(3-nitrophenyl)piperazine (54054-85-2) → 2-methylpropane-1-sulfonic acid {4-[4-(3-nitrophenyl)piperazin-1-yl]butyl}amide (896125-11-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 63 percent / Et₃N / tetrahydrofuran / 48 h / 20 °C

2: CH₂Cl₂ / 2 h / 0 °C

3: Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

With triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm0508641

Reference yield:

4-[4-(3-nitrophenyl)piperazin-1-yl]butylamine tris-trifluoroacetic acid salt + 2-methylpropane-1-sulfonyl chloride (35432-36-1) → 2-methylpropane-1-sulfonic acid {4-[4-(3-nitrophenyl)piperazin-1-yl]butyl}amide (896125-11-4)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1021/jm0508641

Reference yield:

{4-[4-(3-nitrophenyl)piperazin-1-yl]butyl}carbamic acid tert-butyl ester (740873-01-2) → 2-methylpropane-1-sulfonic acid {4-[4-(3-nitrophenyl)piperazin-1-yl]butyl}amide (896125-11-4)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / 2 h / 0 °C

2: Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

With triethylamine; In dichloromethane;

DOI:10.1021/jm0508641

upstream raw materials:

2-methylpropane-1-sulfonyl chloride

{4-[4-(3-nitrophenyl)piperazin-1-yl]butyl}carbamic acid tert-butyl ester

1-(3-nitrophenyl)piperazine

3-nitro-aniline

Downstream raw materials:

N-(3-{4-[4-(2-methylpropane-1-sulfonylamino)butyl]piperazin-1-yl}phenyl)acetamide

2-methylpropane-1-sulfonic acid {4-[4-(3-aminophenyl)piperazin-1-yl]butyl}amide