1-(2-(3-(2-(ethoxymethyl)benzofuran-5-yloxy)-2-hydroxypropylamino)ethyl)-3-(4-hydroxyphenyl)urea

Base Information

Chemical Name:1-(2-(3-(2-(ethoxymethyl)benzofuran-5-yloxy)-2-hydroxypropylamino)ethyl)-3-(4-hydroxyphenyl)urea
CAS No.:1450913-71-9
Molecular Formula:C₂₃H₂₉N₃O₆
Molecular Weight:443.5
Hs Code.:

Synonyms:1-(2-(3-(2-(ethoxymethyl)benzofuran-5-yloxy)-2-hydroxypropylamino)ethyl)-3-(4-hydroxyphenyl)urea

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Chemical Property of 1-(2-(3-(2-(ethoxymethyl)benzofuran-5-yloxy)-2-hydroxypropylamino)ethyl)-3-(4-hydroxyphenyl)urea

Chemical Property:

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Technology Process of 1-(2-(3-(2-(ethoxymethyl)benzofuran-5-yloxy)-2-hydroxypropylamino)ethyl)-3-(4-hydroxyphenyl)urea

There total 7 articles about 1-(2-(3-(2-(ethoxymethyl)benzofuran-5-yloxy)-2-hydroxypropylamino)ethyl)-3-(4-hydroxyphenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1450913-94-6
2-(ethoxymethyl)-5-(oxiran-2-ylmethoxy)benzofuran

: C₉H₁₃N₃O₂*(x)ClH

: 1450913-71-9
1-(2-(3-(2-(ethoxymethyl)benzofuran-5-yloxy)-2-hydroxypropylamino)ethyl)-3-(4-hydroxyphenyl)urea

Guidance literature:: With triethylamine; In water; isopropyl alcohol; acetonitrile; at 90 ℃; for 1h; Microwave irradiation;

Reference yield:

: 853599-45-8
5-(benzyloxy)benzo[b]furan-2-carboxylic acid ethyl ester

: 1450913-71-9
1-(2-(3-(2-(ethoxymethyl)benzofuran-5-yloxy)-2-hydroxypropylamino)ethyl)-3-(4-hydroxyphenyl)urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0 °C / Inert atmosphere

2.2: 20 °C

3.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 20 °C / 2585.81 Torr / Inert atmosphere

4.1: sodium hydroxide / 0.5 h / 120 °C / Microwave irradiation

5.1: triethylamine / acetonitrile; water; isopropyl alcohol / 1 h / 90 °C / Microwave irradiation

With lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; sodium hydride; triethylamine; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile; mineral oil;

Reference yield:

: 912462-48-7
(5-(benzyloxy)benzofuran-2-yl)methanol

: 1450913-71-9
1-(2-(3-(2-(ethoxymethyl)benzofuran-5-yloxy)-2-hydroxypropylamino)ethyl)-3-(4-hydroxyphenyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0 °C / Inert atmosphere

1.2: 20 °C

2.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 20 °C / 2585.81 Torr / Inert atmosphere

3.1: sodium hydroxide / 0.5 h / 120 °C / Microwave irradiation

4.1: triethylamine / acetonitrile; water; isopropyl alcohol / 1 h / 90 °C / Microwave irradiation

With palladium 10% on activated carbon; hydrogen; sodium hydride; triethylamine; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile; mineral oil;