{(2R,4R,5R)-5-[(S)-1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-propyl]-2-phenyl-[1,3]dioxan-4-yl}-methanol

Base Information

Chemical Name:{(2R,4R,5R)-5-[(S)-1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-propyl]-2-phenyl-[1,3]dioxan-4-yl}-methanol
CAS No.:114861-13-1
Molecular Formula:C₂₆H₄₈O₅Si₂
Molecular Weight:496.835
Hs Code.:

Synonyms:{(2R,4R,5R)-5-[(S)-1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-propyl]-2-phenyl-[1,3]dioxan-4-yl}-methanol

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Chemical Property of {(2R,4R,5R)-5-[(S)-1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-propyl]-2-phenyl-[1,3]dioxan-4-yl}-methanol

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Technology Process of {(2R,4R,5R)-5-[(S)-1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-propyl]-2-phenyl-[1,3]dioxan-4-yl}-methanol

There total 8 articles about {(2R,4R,5R)-5-[(S)-1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-propyl]-2-phenyl-[1,3]dioxan-4-yl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1125-88-8
benzaldehyde dimethyl acetal

: 106799-11-5
(2R,3R)-3-[(S)-1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-propyl]-butane-1,2,4-triol

: 114861-13-1
{(2R,4R,5R)-5-[(S)-1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-propyl]-2-phenyl-[1,3]dioxan-4-yl}-methanol

Guidance literature:: camphor-10-sulfonic acid; In benzene; at 25 ℃; for 1h;
DOI:10.1021/ja00241a062

Reference yield:

: 114861-11-9
(3S,4S,5R)-5,6-Bis-benzyloxy-4-benzyloxymethyl-hexane-1,3-diol

: 114861-13-1
{(2R,4R,5R)-5-[(S)-1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-propyl]-2-phenyl-[1,3]dioxan-4-yl}-methanol

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / imidazole / dimethylformamide / 12 h / 0 - 25 °C

2: 95 percent / H₂ / 10percent Pd(OH)2-C / ethanol / 1 h / 25 °C

3: 80 percent / CSA / benzene / 1 h / 25 °C

With 1H-imidazole; hydrogen; palladium hydroxide - carbon; camphor-10-sulfonic acid; In ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1021/ja00241a062

Reference yield:

: 106820-43-3
(4R,5R)-5,6-bis(phenylmethoxy)-4-<(phenylmethoxy)methyl>-2-hexen-1-ol

: 114861-13-1
{(2R,4R,5R)-5-[(S)-1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-propyl]-2-phenyl-[1,3]dioxan-4-yl}-methanol

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / (-)-DET, t-BuOOH, Ti(iPrO)4 / CH₂Cl₂ / 16 h / -20 °C

2: 97 percent / REDAL / tetrahydrofuran / 4 h / 0 °C

3: 89 percent / imidazole / dimethylformamide / 12 h / 0 - 25 °C

4: 95 percent / H₂ / 10percent Pd(OH)2-C / ethanol / 1 h / 25 °C

5: 80 percent / CSA / benzene / 1 h / 25 °C

With 1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; hydrogen; (-)-diethyl tartrate; sodium bis(2-methoxyethoxy)aluminium dihydride; palladium hydroxide - carbon; camphor-10-sulfonic acid; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/ja00241a062