2-Allyl-2-[(E)-3-(4-formyl-phenyl)-allyl]-malonic acid diethyl ester

Base Information

• Chemical Name: 2-Allyl-2-[(E)-3-(4-formyl-phenyl)-allyl]-malonic acid diethyl ester
• CAS No.: 190841-45-3
• Molecular Formula: C₂₀H₂₄O₅
• Molecular Weight: 344.408
• Mol file: 190841-45-3.mol

Synonyms:2-Allyl-2-[(E)-3-(4-formyl-phenyl)-allyl]-malonic acid diethyl ester

Chemical Property of 2-Allyl-2-[(E)-3-(4-formyl-phenyl)-allyl]-malonic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Allyl-2-[(E)-3-(4-formyl-phenyl)-allyl]-malonic acid diethyl ester

There total 1 articles about 2-Allyl-2-[(E)-3-(4-formyl-phenyl)-allyl]-malonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-propenyl)propanedioic acid diethyl ester (2049-80-1) + terephthalaldehyde, (623-27-8) + vinyltriphenylphosphonium bromide (5044-52-0) → 2-Allyl-2-[(E)-3-(4-formyl-phenyl)-allyl]-malonic acid diethyl ester (190841-45-3)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) Et₂O, r.t., 1 h; 2.) DMF, 100 deg C, 2 d;

DOI:10.1055/s-1997-790

Reference yield: 88.0%

propylamine (107-10-8,42939-71-9) + 2-Allyl-2-[(E)-3-(4-formyl-phenyl)-allyl]-malonic acid diethyl ester (190841-45-3) → 2-Allyl-2-[(E)-3-(4-propylaminomethyl-phenyl)-allyl]-malonic acid diethyl ester (190841-51-1)

Guidance literature:

With sodium cyanoborohydride; In acetic acid; N,N-dimethyl-formamide; for 12h; Ambient temperature;

DOI:10.1055/s-1997-790

Reference yield: 80.0%

2-Allyl-2-[(E)-3-(4-formyl-phenyl)-allyl]-malonic acid diethyl ester (190841-45-3) → 2-Allyl-2-[(E)-3-(4-formyl-phenyl)-allyl]-malonic acid monoethyl ester (190841-46-4)

Guidance literature:

With potassium hydroxide; In ethanol; water; for 12h; Ambient temperature;

DOI:10.1055/s-1997-790

upstream raw materials:

(2-propenyl)propanedioic acid diethyl ester

terephthalaldehyde,

vinyltriphenylphosphonium bromide

Downstream raw materials:

2-Allyl-2-[(E)-3-(4-propylaminomethyl-phenyl)-allyl]-malonic acid diethyl ester

2-Allyl-2-[(E)-3-(4-formyl-phenyl)-allyl]-malonic acid monoethyl ester