6-[[3-(2,6-dimethyl-4-prop-1-ynyl-phenyl)-2,4-dioxo-cyclopentyl]methyl]-2-(methylamino)pyridine-3-carbonitrile

Base Information

Chemical Name:6-[[3-(2,6-dimethyl-4-prop-1-ynyl-phenyl)-2,4-dioxo-cyclopentyl]methyl]-2-(methylamino)pyridine-3-carbonitrile
CAS No.:1439559-04-2
Molecular Formula:C₂₄H₂₃N₃O₂
Molecular Weight:385.466
Hs Code.:

Synonyms:6-[[3-(2,6-dimethyl-4-prop-1-ynyl-phenyl)-2,4-dioxo-cyclopentyl]methyl]-2-(methylamino)pyridine-3-carbonitrile

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Chemical Property of 6-[[3-(2,6-dimethyl-4-prop-1-ynyl-phenyl)-2,4-dioxo-cyclopentyl]methyl]-2-(methylamino)pyridine-3-carbonitrile

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Technology Process of 6-[[3-(2,6-dimethyl-4-prop-1-ynyl-phenyl)-2,4-dioxo-cyclopentyl]methyl]-2-(methylamino)pyridine-3-carbonitrile

There total 10 articles about 6-[[3-(2,6-dimethyl-4-prop-1-ynyl-phenyl)-2,4-dioxo-cyclopentyl]methyl]-2-(methylamino)pyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1439558-98-1
6-[[3-(2,6-dimethyl-4-prop-1-ynyl-phenyl)-4-methoxy-2-oxo-cyclopent-3-en-1-yl]methyl]-2-(methylamino)pyridine-3-carbonitrile

: 1439559-04-2
6-[[3-(2,6-dimethyl-4-prop-1-ynyl-phenyl)-2,4-dioxo-cyclopentyl]methyl]-2-(methylamino)pyridine-3-carbonitrile

Guidance literature:: 6-[[3-(2,6-dimethyl-4-prop-1-ynyl-phenyl)-4-methoxy-2-oxo-cyclopent-3-en-1-yl]methyl]-2-(methylamino)pyridine-3-carbonitrile; With hydrogenchloride; In water; acetone; at 60 ℃; for 5h;

With potassium carbonate; In water;

Reference yield:

: 1203555-00-3
2-(4-bromo-2,6-dimethyl-phenyl)-3-methoxy-cyclopent-2-en-1-one

: 1439559-04-2
6-[[3-(2,6-dimethyl-4-prop-1-ynyl-phenyl)-2,4-dioxo-cyclopentyl]methyl]-2-(methylamino)pyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 8 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C

2: triethylamine / dichloromethane / 20 °C

3: potassium carbonate / methanol / 60 °C

4: acetic acid; zinc / 20 °C

5: urea hydrogen peroxide adduct; trifluoroacetic anhydride / dichloromethane / 4 h / 0 °C

6: tetrahydrofuran / 3 h / 20 °C

7: cesium fluoride; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 1.5 h / 120 °C / Inert atmosphere; Microwave irradiation

8: hydrogenchloride / acetone; water / 5 h / 60 °C

With hydrogenchloride; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; urea hydrogen peroxide adduct; potassium carbonate; acetic acid; triethylamine; cesium fluoride; trifluoroacetic anhydride; lithium hexamethyldisilazane; zinc; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1237529-42-8
2-(4-bromo-2,6-dimethylphenyl)cyclopent-4-ene-1,3-dione

: 1439559-04-2
6-[[3-(2,6-dimethyl-4-prop-1-ynyl-phenyl)-2,4-dioxo-cyclopentyl]methyl]-2-(methylamino)pyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 10 steps

1: acetic acid; zinc / 2 h / 90 °C

2: potassium carbonate / acetone / 16 h / 25 - 30 °C

3: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C

4: triethylamine / dichloromethane / 20 °C

5: potassium carbonate / methanol / 60 °C

6: acetic acid; zinc / 20 °C

7: urea hydrogen peroxide adduct; trifluoroacetic anhydride / dichloromethane / 4 h / 0 °C

8: tetrahydrofuran / 3 h / 20 °C

9: cesium fluoride; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 1.5 h / 120 °C / Inert atmosphere; Microwave irradiation

10: hydrogenchloride / acetone; water / 5 h / 60 °C

With hydrogenchloride; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; urea hydrogen peroxide adduct; potassium carbonate; acetic acid; triethylamine; cesium fluoride; trifluoroacetic anhydride; lithium hexamethyldisilazane; zinc; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;