diethyl 6-(3-bromophenyl)-3-{[3-(4-methoxyphenyl)-4,5-dihydro-5-isoxazolyl]methyl}-2-oxo-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylate

Base Information

Chemical Name:diethyl 6-(3-bromophenyl)-3-{[3-(4-methoxyphenyl)-4,5-dihydro-5-isoxazolyl]methyl}-2-oxo-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylate
CAS No.:1352412-26-0
Molecular Formula:C₂₇H₂₈BrN₃O₇
Molecular Weight:586.439
Hs Code.:

Synonyms:diethyl 6-(3-bromophenyl)-3-{[3-(4-methoxyphenyl)-4,5-dihydro-5-isoxazolyl]methyl}-2-oxo-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylate

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Chemical Property of diethyl 6-(3-bromophenyl)-3-{[3-(4-methoxyphenyl)-4,5-dihydro-5-isoxazolyl]methyl}-2-oxo-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylate

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Technology Process of diethyl 6-(3-bromophenyl)-3-{[3-(4-methoxyphenyl)-4,5-dihydro-5-isoxazolyl]methyl}-2-oxo-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylate

There total 2 articles about diethyl 6-(3-bromophenyl)-3-{[3-(4-methoxyphenyl)-4,5-dihydro-5-isoxazolyl]methyl}-2-oxo-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1352412-17-9
diethyl 3-allyl-6-(3-bromophenyl)-2-oxo-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylate

: 38435-51-7
N-hydroxy-4-methoxy-benzenecarboximidoyl chloride

: 1352412-26-0
diethyl 6-(3-bromophenyl)-3-{[3-(4-methoxyphenyl)-4,5-dihydro-5-isoxazolyl]methyl}-2-oxo-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylate

Guidance literature:: With triethylamine; In dichloromethane; at -15 - 20 ℃; for 13h; regioselective reaction;
DOI:10.1134/S1070428011110133

Reference yield:

: 881993-37-9
(3-bromophenyl)chloromethyl isocyanate

: 1352412-11-3
diethyl N-allylaminofumarate

: 1352412-26-0
diethyl 6-(3-bromophenyl)-3-{[3-(4-methoxyphenyl)-4,5-dihydro-5-isoxazolyl]methyl}-2-oxo-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / 24 h / 20 °C

2: triethylamine / dichloromethane / 13 h / -15 - 20 °C

With triethylamine; In dichloromethane; toluene;
DOI:10.1134/S1070428011110133