N₁-[2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-acetyl]-N₄-n-butyl thiosemicarbazide

Base Information

• Chemical Name: N₁-[2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-acetyl]-N₄-n-butyl thiosemicarbazide
• CAS No.: 867154-23-2
• Molecular Formula: C₂₄H₂₇ClN₄O₃S
• Molecular Weight: 487.022

Synonyms:N₁-[2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-acetyl]-N₄-n-butyl thiosemicarbazide

Chemical Property of N₁-[2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-acetyl]-N₄-n-butyl thiosemicarbazide

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₁-[2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-acetyl]-N₄-n-butyl thiosemicarbazide

There total 2 articles about N₁-[2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-acetyl]-N₄-n-butyl thiosemicarbazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

butyl isothiocyanate (592-82-5) + [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid hydrazide (867154-15-2) → N1-[2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-acetyl]-N4-n-butyl thiosemicarbazide (867154-23-2)

Guidance literature:

In ethanol; for 10h; Heating;

DOI:10.1002/ardp.200400891

Reference yield:

indomethacin ethyl ester (16401-99-3) → N1-[2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-acetyl]-N4-n-butyl thiosemicarbazide (867154-23-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / hydrazine hydrate / ethanol / 30 h / Heating

2: 90 percent / ethanol / 10 h / Heating

With hydrazine hydrate; In ethanol;

DOI:10.1002/ardp.200400891

Reference yield: 63.0%

N1-[2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-acetyl]-N4-n-butyl thiosemicarbazide (867154-23-2) → 5-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-ylmethyl]-4-n-butyl-3-mercapto-4H-1,2,4-triazole

Guidance literature:

With sodium hydroxide; In ethanol; Heating;

DOI:10.1002/ardp.200400891

upstream raw materials:

butyl isothiocyanate

[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid hydrazide

indomethacin ethyl ester

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