7-Chloro-9-piperidin-1-yl-1,2,3,4-tetrahydroacridine

Base Information

Chemical Name:7-Chloro-9-piperidin-1-yl-1,2,3,4-tetrahydroacridine
CAS No.:5398-80-1
Molecular Formula:C₁₈H₂₁ClN₂
Molecular Weight:300.831
Hs Code.:
NSC Number:3615
DSSTox Substance ID:DTXSID50277700
Wikidata:Q82009039
Mol file:5398-80-1.mol

Synonyms:5398-80-1;7-chloro-9-(piperidin-1-yl)-1,2,3,4-tetrahydroacridine;7-chloro-9-piperidin-1-yl-1,2,3,4-tetrahydroacridine;NSC3615;DTXSID50277700;NSC 3615;NSC-3615

Suppliers and Price of 7-Chloro-9-piperidin-1-yl-1,2,3,4-tetrahydroacridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 7-Chloro-9-piperidin-1-yl-1,2,3,4-tetrahydroacridine

Chemical Property:

Vapor Pressure:5.75E-10mmHg at 25°C
Boiling Point:495.7°Cat760mmHg
Flash Point:253.6°C
Density:1.213g/cm³
XLogP3:5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:300.1393264
Heavy Atom Count:21
Complexity:355

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCN(CC1)C2=C3CCCCC3=NC4=C2C=C(C=C4)Cl

Technology Process of 7-Chloro-9-piperidin-1-yl-1,2,3,4-tetrahydroacridine

There total 4 articles about 7-Chloro-9-piperidin-1-yl-1,2,3,4-tetrahydroacridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 110-89-4
piperidine

: 1629174-85-1
7-chloro-1,2,3,4-tetrahydroacridin-9-yl trifluoromethanesulfonate

: 5398-80-1
7-chloro-9-(piperidin-1-yl)-1,2,3,4-tetrahydroacridine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; at 130 ℃; for 1h; Microwave irradiation; Inert atmosphere;
DOI:10.1002/ejoc.201402122

Reference yield:

: 110-89-4
piperidine

: 53618-66-9
4,6-Dichloro-2,3-tetramethylenequinoline

: 5398-80-1
7-chloro-9-(piperidin-1-yl)-1,2,3,4-tetrahydroacridine

Guidance literature:: With copper; at 180 ℃; unter Druck;
DOI:10.1021/jo01168a013

Reference yield:

: 113106-05-1,643757-30-6
7-chloro-1,2,3 ,4-tetrahydroacridin-9-(10H)-one

: 5398-80-1
7-chloro-9-(piperidin-1-yl)-1,2,3,4-tetrahydroacridine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 17 h / -78 - 20 °C / Inert atmosphere

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / 1,4-dioxane / 1 h / 130 °C / Microwave irradiation; Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; In 1,4-dioxane; dichloromethane; 2: |Buchwald-Hartwig Coupling;
DOI:10.1002/ejoc.201402122