((2R,3S)-1-Acetyl-2-isopropoxy-5-oxo-pyrrolidin-3-yl)-benzenesulfonyl-acetic acid methyl ester

Base Information

• Chemical Name: ((2R,3S)-1-Acetyl-2-isopropoxy-5-oxo-pyrrolidin-3-yl)-benzenesulfonyl-acetic acid methyl ester
• CAS No.: 201014-16-6
• Molecular Formula: C₁₈H₂₃NO₇S
• Molecular Weight: 397.449
• Mol file: 201014-16-6.mol

Synonyms:((2R,3S)-1-Acetyl-2-isopropoxy-5-oxo-pyrrolidin-3-yl)-benzenesulfonyl-acetic acid methyl ester

Chemical Property of ((2R,3S)-1-Acetyl-2-isopropoxy-5-oxo-pyrrolidin-3-yl)-benzenesulfonyl-acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((2R,3S)-1-Acetyl-2-isopropoxy-5-oxo-pyrrolidin-3-yl)-benzenesulfonyl-acetic acid methyl ester

There total 1 articles about ((2R,3S)-1-Acetyl-2-isopropoxy-5-oxo-pyrrolidin-3-yl)-benzenesulfonyl-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl benzenesulfonylacetate (34097-60-4) + (R)-1-acetyl-5-isopropoxy-3-pyrrolin-2-one (138259-70-8) → ((2R,3S)-1-Acetyl-2-isopropoxy-5-oxo-pyrrolidin-3-yl)-benzenesulfonyl-acetic acid methyl ester (201014-16-6)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jo971854d

Reference yield: 80.0%

(4-Iodo-but-2-ynyl)-trimethyl-silane (111097-70-2) + ((2R,3S)-1-Acetyl-2-isopropoxy-5-oxo-pyrrolidin-3-yl)-benzenesulfonyl-acetic acid methyl ester (201014-16-6) → 2-((2R,3S)-1-Acetyl-2-isopropoxy-5-oxo-pyrrolidin-3-yl)-2-benzenesulfonyl-6-trimethylsilanyl-hex-4-ynoic acid methyl ester (201014-21-3)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; for 18h; Ambient temperature;

DOI:10.1021/jo971854d

Reference yield:

((2R,3S)-1-Acetyl-2-isopropoxy-5-oxo-pyrrolidin-3-yl)-benzenesulfonyl-acetic acid methyl ester (201014-16-6) → (3aS,6aR)-4-Benzenesulfonyl-6-vinylidene-hexahydro-cyclopenta[b]pyrrol-2-one (201014-31-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / NaH / dimethylformamide / 18 h / Ambient temperature

2: 80 percent / formic acid / dimethylformamide

3: 1.) LiOH, 2.) pyridine / 1.) THF, H₂O, 2.) 90 deg C

With pyridine; lithium hydroxide; formic acid; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1021/jo971854d

upstream raw materials:

methyl benzenesulfonylacetate

(R)-1-acetyl-5-isopropoxy-3-pyrrolin-2-one

Downstream raw materials:

2-((2R,3S)-1-Acetyl-2-isopropoxy-5-oxo-pyrrolidin-3-yl)-2-benzenesulfonyl-6-trimethylsilanyl-hex-4-ynoic acid methyl ester

(3aS,6aR)-4-Benzenesulfonyl-6-vinylidene-hexahydro-cyclopenta[b]pyrrol-2-one

(3aR,6aR)-1-(Toluene-4-sulfonyl)-1,3,3a,6a-tetrahydro-cyclopenta[b]pyrrole-2,6-dione

(3aR,4R,6aR)-4-Isopropyl-1-(toluene-4-sulfonyl)-hexahydro-cyclopenta[b]pyrrole-2,6-dione