1-(2,5-difluoro-4-(methylsulfonyl)benzyl)-3-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidin-4-yl)imidazolidin-2-one

Base Information

Chemical Name:1-(2,5-difluoro-4-(methylsulfonyl)benzyl)-3-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidin-4-yl)imidazolidin-2-one
CAS No.:1437800-21-9
Molecular Formula:C₁₉H₂₀F₅N₅O₄S
Molecular Weight:509.457
Hs Code.:

Synonyms:1-(2,5-difluoro-4-(methylsulfonyl)benzyl)-3-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidin-4-yl)imidazolidin-2-one

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Chemical Property of 1-(2,5-difluoro-4-(methylsulfonyl)benzyl)-3-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidin-4-yl)imidazolidin-2-one

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Technology Process of 1-(2,5-difluoro-4-(methylsulfonyl)benzyl)-3-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidin-4-yl)imidazolidin-2-one

There total 10 articles about 1-(2,5-difluoro-4-(methylsulfonyl)benzyl)-3-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidin-4-yl)imidazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1437801-35-8
4-(3-(2,5-difluoro-4-(methylsulfonyl)benzyl)-2-oxoimidazolidin-1-yl)piperidine-1-carbonitrile

: 407-25-0
trifluoroacetic anhydride

: 1437800-21-9
1-(2,5-difluoro-4-(methylsulfonyl)benzyl)-3-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidin-4-yl)imidazolidin-2-one

Guidance literature:: 4-(3-(2,5-difluoro-4-(methylsulfonyl)benzyl)-2-oxoimidazolidin-1-yl)piperidine-1-carbonitrile; With hydroxylamine; In tetrahydrofuran; water; at 60 ℃; for 4h;

trifluoroacetic anhydride; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 1437800-76-4
benzyl 4-bromo-2,5-difluorobenzyl(2-((tert-butoxycarbonyl)amino)ethyl)carbamate

: 1437800-21-9
1-(2,5-difluoro-4-(methylsulfonyl)benzyl)-3-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidin-4-yl)imidazolidin-2-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: dichloromethane / 1 h / 20 °C

2.1: acetic acid / tetrahydrofuran / 0.5 h / 20 °C

2.2: 20 °C

3.1: rac-diaminocyclohexane; copper (I) trifluoromethane sulfonate benzene / dimethyl sulfoxide / 110 °C / Inert atmosphere

4.1: palladium 10% on activated carbon; hydrogen / methanol; water / 2 h / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4 h / 60 °C

6.1: dichloromethane / 1 h / 20 °C

7.1: sodium hydrogencarbonate / tetrahydrofuran; water; acetonitrile / 2 h / 20 °C

8.1: hydroxylamine / tetrahydrofuran; water / 4 h / 60 °C

8.2: 20 °C

With copper (I) trifluoromethane sulfonate benzene; palladium 10% on activated carbon; hydrogen; hydroxylamine; sodium hydrogencarbonate; acetic acid; rac-diaminocyclohexane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 1437800-78-6
benzyl 2-aminoethyl(4-bromo-2,5-difluorobenzyl)carbamate trifluoroacetic acid

: 1437800-21-9
1-(2,5-difluoro-4-(methylsulfonyl)benzyl)-3-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidin-4-yl)imidazolidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetic acid / tetrahydrofuran / 0.5 h / 20 °C

1.2: 20 °C

2.1: rac-diaminocyclohexane; copper (I) trifluoromethane sulfonate benzene / dimethyl sulfoxide / 110 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / methanol; water / 2 h / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4 h / 60 °C

5.1: dichloromethane / 1 h / 20 °C

6.1: sodium hydrogencarbonate / tetrahydrofuran; water; acetonitrile / 2 h / 20 °C

7.1: hydroxylamine / tetrahydrofuran; water / 4 h / 60 °C

7.2: 20 °C

With copper (I) trifluoromethane sulfonate benzene; palladium 10% on activated carbon; hydrogen; hydroxylamine; sodium hydrogencarbonate; acetic acid; rac-diaminocyclohexane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile;