3-(2,2-dimethoxyethylidene)-1-methyl-5-(toluene-4-sulfonyl)piperidine-2,6-dione

Base Information

Chemical Name:3-(2,2-dimethoxyethylidene)-1-methyl-5-(toluene-4-sulfonyl)piperidine-2,6-dione
CAS No.:952228-91-0
Molecular Formula:C₁₇H₂₁NO₆S
Molecular Weight:367.423
Hs Code.:

Synonyms:3-(2,2-dimethoxyethylidene)-1-methyl-5-(toluene-4-sulfonyl)piperidine-2,6-dione

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Chemical Property of 3-(2,2-dimethoxyethylidene)-1-methyl-5-(toluene-4-sulfonyl)piperidine-2,6-dione

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Technology Process of 3-(2,2-dimethoxyethylidene)-1-methyl-5-(toluene-4-sulfonyl)piperidine-2,6-dione

There total 1 articles about 3-(2,2-dimethoxyethylidene)-1-methyl-5-(toluene-4-sulfonyl)piperidine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: C₁₀H₁₆O₆

: 500586-84-5
2-tolylsulfonyl N-methylacetamide

: 952228-91-0
3-(2,2-dimethoxyethylidene)-1-methyl-5-(toluene-4-sulfonyl)piperidine-2,6-dione

Guidance literature:: 2-tolylsulfonyl N-methylacetamide; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.5h;

C₁₀H₁₆O₆; In tetrahydrofuran; at 20 ℃; for 0.25h; Further stages.;
DOI:10.1016/j.tet.2007.06.101

Reference yield: 95.0%

: 952228-91-0
3-(2,2-dimethoxyethylidene)-1-methyl-5-(toluene-4-sulfonyl)piperidine-2,6-dione

: 952228-92-1
3-(2,2-dimethoxyethyl)-1-methyl-5-(toluene-4-sulfonyl)piperidine-2,6-dione

Guidance literature:: With hydrogen; Raney nickel 2800; In tetrahydrofuran; water; at 20 ℃; for 12h; under 2068.65 Torr;
DOI:10.1016/j.tet.2007.06.101

Reference yield:

: 952228-91-0
3-(2,2-dimethoxyethylidene)-1-methyl-5-(toluene-4-sulfonyl)piperidine-2,6-dione

: 5-methyl-2,3-(methylenedioxy)-6a-(toluene-4-sulfonyl)-6a,7,10,10a-tetrahydrobenzo[c]phenanthridin-6(5H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: 95 percent / H₂ / Raney nickel 2800 / tetrahydrofuran; H₂O / 12 h / 20 °C / 2068.65 Torr

2.1: 93 percent / boron trifluoride diethyl ether complex; MgSO₄ / CH₂Cl₂ / 20 h / -30 °C

3.1: 83 percent / DDQ / toluene / 24 h / Heating

4.1: 98 percent / tetrahydrofuran / 1.5 h / 20 °C

5.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C

5.2: 94 percent / tetrahydrofuran / 30 h / 20 °C

6.1: 96 percent / first generation Grubbs catalyst / CH₂Cl₂ / 7.5 h / 20 °C

With boron trifluoride diethyl etherate; hydrogen; sodium hydride; magnesium sulfate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; Grubbs catalyst first generation; Raney nickel 2800; In tetrahydrofuran; dichloromethane; water; toluene;
DOI:10.1016/j.tet.2007.06.101