(R)-2-(2-methoxy-4-methylphenyl)propan-1-ol

Base Information

Chemical Name:(R)-2-(2-methoxy-4-methylphenyl)propan-1-ol
CAS No.:1313051-46-5
Molecular Formula:C₁₁H₁₆O₂
Molecular Weight:180.247
Hs Code.:

Synonyms:(R)-2-(2-methoxy-4-methylphenyl)propan-1-ol

Suppliers and Price of (R)-2-(2-methoxy-4-methylphenyl)propan-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-(2-methoxy-4-methylphenyl)propan-1-ol

Chemical Property:

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Technology Process of (R)-2-(2-methoxy-4-methylphenyl)propan-1-ol

There total 4 articles about (R)-2-(2-methoxy-4-methylphenyl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108-05-4,9003-20-7
vinyl acetate

: 55919-62-5
2-(2-methoxy-4-methylphenyl)propan-1-ol

: 1313051-46-5
(R)-2-(2-methoxy-4-methylphenyl)propan-1-ol

: 1313051-09-0
C₁₃H₁₈O₃

Guidance literature:: vinyl acetate; 2-(2-methoxy-4-methylphenyl)propan-1-ol; With Porcine pancreas lipase type II; In tert-butyl methyl ether; at 20 ℃; Enzymatic reaction;

With methanol; sodium hydroxide; for 6h; Reflux;

vinyl acetate; With Porcine pancreas lipase type II; In tert-butyl methyl ether; optical yield given as %ee; enantioselective reaction; Enzymatic reaction;
DOI:10.1016/j.tetasy.2011.03.012

Reference yield:

: β-oxy-β-(2-methoxy-4-methyl-phenyl)-propane

: 1313051-46-5
(R)-2-(2-methoxy-4-methylphenyl)propan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid; hydroquinone / benzene / Reflux; Azeotropic water removal

2.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2.2: 1 h / 20 - 40 °C

2.3: 20 - 30 °C

3.1: Porcine pancreas lipase type II / tert-butyl methyl ether / 20 °C / Enzymatic reaction

3.2: 6 h / Reflux

3.3: Enzymatic reaction

With Porcine pancreas lipase type II; dimethylsulfide borane complex; toluene-4-sulfonic acid; hydroquinone; In tetrahydrofuran; tert-butyl methyl ether; benzene;
DOI:10.1016/j.tetasy.2011.03.012

Reference yield:

: 35633-35-3
2-methoxy-4-methylacetophenone

: 1313051-46-5
(R)-2-(2-methoxy-4-methylphenyl)propan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: diethyl ether / 3.5 h / 0 - 20 °C / Inert atmosphere

1.2: Cooling with ice

2.1: toluene-4-sulfonic acid; hydroquinone / benzene / Reflux; Azeotropic water removal

3.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

3.2: 1 h / 20 - 40 °C

3.3: 20 - 30 °C

4.1: Porcine pancreas lipase type II / tert-butyl methyl ether / 20 °C / Enzymatic reaction

4.2: 6 h / Reflux

4.3: Enzymatic reaction

With Porcine pancreas lipase type II; dimethylsulfide borane complex; toluene-4-sulfonic acid; hydroquinone; In tetrahydrofuran; diethyl ether; tert-butyl methyl ether; benzene;
DOI:10.1016/j.tetasy.2011.03.012